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Acyclovir Review Article

 

ZoviraxAcyclovir or Aciclovir (Brand names: Zovirax, Telviran. Chemical Name: acycloguanosine/ACV), is a gunosine analogue oral antiviral drug, which is commonly used and is extremely selective and has low level of cytotoxicity. It is mainly used for treating herpes simplex virus infections and herpes zoster (shingles). Zovirax relieves the symptoms and reduces the period of time the virus is active but does not totally cure the disease.

Acyclovir is time-tested, effective antiviral medication for herpes

Acyclovir is the international nonproprietary name of a drug called acycloguanosine which is a guanosine analogue. It is used as an antiviral drug for common sexually transmitted diseases such as herpes, Epstein-Barr virus, cytomegalovirus varicella zoster and herpes zoster. It is included in the latest breed of antiviral therapy medication because of low cytotoxicity and extreme selectiveness. This drug is also chosen because of rare occurrence of resistance. When Acyclovir is taken in, it is in a dormant or weakened state which is then activated after the body metabolizes it. Continue reading...

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2 g Acyclovir cream 5% (Telviran) USD 12.00 Add to Basket
2 g Acyclovir cream 5% (Zovirax) USD 20.00 Add to Basket
5 g Acyclovir cream 5% (Herpesin) USD 19.00 Add to Basket
200 mg 25 tab ($1.36 per tab) USD 34.00 Add to Basket
200 mg 50 tab ($1.32 per tab) USD 66.00 Add to Basket
400 mg 35 tab ($2.14 per tab) USD 75.00 Add to Basket
400 mg 70 tab ($2.06 per tab) USD 144.00 Add to Basket
800 mg 35 tab ($3.11 per tab) USD 109.00 Add to Basket
800 mg 70 tab ($2.96 per tab) USD 207.00 Add to Basket

In a recent clinical trial, Acyclovir was used in another yet more controversial type of STD virus—HIV. Though not uncommon, the use of Acyclovir for this virus is still under a young stage of study. Additionally, because of Acyclovir’s use for Herpes which is a co-factor for transmitting and infecting others with HIV, researchers saw this as an opportunity to significantly decrease HIV infection. The study took place in Thailand and involved 65 women from ages 18 to 49 years old infected with HIV-1 and HSV-2. No timeframe has been set but the study has been completed. The participants underwent suppressive therapy of Acyclovir and have shown results regarding reduction of HIV transmission or development as connected with the virus’ genital shedding.

On another clinical trial, no definite results were shown but indications of using Acyclovir alone as opposed to 15% SP-303 gel combined with Acyclovir were sufficient enough to treat both Herpes Simplex Virus 1 and 2. The areas that affected the participants were the genital, perianal and nearby regions of the bodies. Also included in the study were those affected by AIDS. The first group received topical treatment of the gel along with oral form of Acyclovir while the other took in Acyclovir alone orally. Both groups did this 3 times a day and were evaluated for any mending of lesions 3 times weekly.

As STD’s are commonly transmitted by women to their children if still infected and passed through the vaginal birth canal, researchers have also tried to use Acyclovir and evaluate its effectiveness in eradicate the Herpes Simplex Virus infection that most of the neonates have. This virus will mostly infect the Central Nervous System of the neonate such as the brain or spine while others were mildly inflicted on their skin. Both types of infections were included in the randomized study for oral and inactive Acyclovir. This study lasted for 5 years which entailed long term treatment of the drug. There were periodic physical, hearing, eye and CNS exams to check for progress. While this study is currently active, a previous similar study showed positive changes on the conditions of the participants which were given Acyclovir intravenously.

Reference:

1. Dunne, E.F., 2008. A Randomized Controlled Trial of Acyclovir Among HIV and HSV-2 Co-Infected Women, Chiang Rai, Thailand.

2. Shaman Pharmaceuticals (Sponsor). 2008. Double-Blind Placebo-Controlled Study Comparing the Combination of 15% SP-303 Gel With Acyclovir Versus Acyclovir Alone for the Treatment of Recurrent Herpes Simplex Virus (HSV) Infections in Subjects With Acquired Immunodeficiency Syndrome (AIDS).

3. National Institute of Allergy and infectious Diseases (Sponsor). 2008. Acyclovir for Herpes Infections Involving the Central Nervous System in Neonates.


 

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