Life-extension drugs

Life-extension drugs

Astragaloside IV prescribing information

 

Planta Med. 2012 Jan;78(2):115-21. Epub 2011 Nov 14.
Yung LY, Lam WS, Ho MK, Hu Y, Ip FC, Pang H, Chin AC, Harley CB, Ip NY, Wong YH.
Biotechnology Research Institute and Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.

Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types.

Two Chinese herb-derived small molecule telomerase activators, astragaloside IV (AG-IV) and cycloastragenol (CAG), have recently been shown to improve the proliferative response of CD8+ T lymphocytes from HIV-infected patients by upregulating telomerase activity. Here, we examined the signaling mechanism of AG-IV and CAG. Telomerase activity in human embryonic kidney HEK293 fibroblasts was increased upon treatment with increasing concentrations of AG-IV or CAG. Both compounds induced the phosphorylation of extracellular signal-regulated protein kinase (ERK) in a time- and dose-dependent manner in HEK293 cells and HEK-neo keratinocytes. AG-IV and CAG also stimulated ERK phosphorylation in other cell lines of lung, brain, mammary, endothelial, and hematopoietic origins. Use of selective inhibitors and dominant negative mutants revealed the involvement of c-Src, MEK (ERK kinase), and epidermal growth factor receptor in CAG-induced ERK phosphorylation. Our data indicate that AG-IV and CAG may exert their cellular effects through the activation of the Src/MEK/ERK pathway.


Astragaloside IV review article...

 

My BasketMy Basket

Geroprotector
Astragaloside IV
Astragaloside IV prescribing information


Buy here


Astragaloside IV review article


Newsletter subscription


Product search

Product list

- ASTRAGALOSIDE IV
- AVEMAR IMMUNE BOOSTER
- B-VITAMIN COMPLEX
- B-VITAMIN COMPLEX FORTE
- B6 VITAMIN
- BURDOCK ROOT OIL
- CAFFEINE COMPLEX
- CALCITRIO
- CAVINTON
- COENZYME Q10
- CYCLOASTRAGENOL (TA-65 ACTIVE SUBSTANCE)
- D3 VITAMIN
- E VITAMIN
- ECHINACEA/ VIT. C 1000/ ZINC
- FAT BURNER
- FISH OIL
- FOLIC ACID
- IMUNOVIR
- INULIN
- IODIDE (KI)
- IODINE WATER
- ISOPRINOSINE
- K-2 VITAMIN
- LEUZEA ROOT
- LIFE EXTENDING KIT
- LIPITOR
- LIPOIC ACID
- MACA VIBE
- MEMANTINE
- MUMIJO (MUMIO)
- NADH
- NOOTROPYL
- PIRACETAM
- PUMPKINSEED OIL
- RED WINE HIGH IN RESVERATROL
- RESVERATROL
- REVALID CAPSULES
- REVALID CREAM
- REVALID HAIR TONIC
- REVALID SHAMPOO AND CONDITIONER
- RHODIOLA ROOT
- RHODIOLA TABLETS
- RUTIN
- SCHISANDRA
- SEA-BUCKTHORN
- SELENIUM
- THIOGAMMA (LIPOIC ACID)
- ZINC (ZN)

You are located on a secure website.
Customer data is for our internal use only and will be treated as confidential.

eXTReMe Tracker