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Atorvastatin prescribing information

 



Atorvastatin notes

Atorvastatin (brand name Lipitor) is an oral drug used for lowering cholesterol levels in the blood. It also stabilizes plaque and prevents strokes through anti – inflammatory mechanisms. It belongs to the class of drugs referred to as statins. All statins, including Atorvastatin, prevent the production of cholesterol in the liver by blocking HMG-CoA reductase, an enzyme that makes cholesterol.

Atorvastatin, also reduces the concentration of triglycerides in the blood and raises the concentrations of HDL cholesterol, which is known to be the “good” blood cholesterol. Atorvastatin has rapid oral absorption with an approximate time to maximum plasma concentration of 1–2 hours.

Precaution must be taken when treating with atorvastatin, because it may lead to rhabdomyolysis, which may be very serious leading to acute renal failure due to myoglobinuria. If rhabdomyolysis is suspected or diagnosed, atorvastatin therapy should be discontinued immediately. In addition, Atorvastatin should be discontinued if a patient has markedly elevated CPK levels or if a myopathy is suspected or diagnosed.

The elderly patients show a greater pharmacodynamic response to atorvastatin at any dose, therefore, this population may have lower effective doses. It has also been used in the treatment of combined hyperlipidemia and is absolutely contraindicated in the case of pregnancy due to the possibility of adverse reactions.


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