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Azopt Review Article

 

TextAzopt (Genric Name: Brinzolamide) is used to lessen intraocular pressure or the pressure inside the eye in individuals suffering from ocular hypertension, wherein the pressure inside the eye is elevated or higher than normal, or open-angle glaucoma, an illness wherein the pressure inside the eye is raised since fluid cannot be drained out of the eye. This drug is a carbonic anhydrase inhibitor. It works by inhibiting an enzyme termed carbonic anhydrase that synthesizes bicarbonate ions in the body. Bicarbonate is essential in the production of the aqueous humour which is the watery fluid inside the eye. By preventing the synthesis of bicorbonate in the eye, Azopt dekays the creation of aqueous humour and thus reduces the pressure inside the eye. Common side effects include headache, dysgeusia, inflammation of the eyelids, eye irritation, blurred vision, eye discharge, dry eye, itchy eyes, red eye, dry mouth, and sensation of a foreign body in the eyes.

Azopt is an ocular (eye) drug used to treat eye problems such as glaucoma which results in an increased intraocular pressure. This rise in pressure could be due to fluid retention within the eye as it occurs in glaucoma or due to ocular hypertension. Azopt acts by inhibiting the action of carbonic anhydrase which synthesizes bicarbonate ions. These ions are involved in the process of fluid formation within the eye. By inhibiting the action of carboic anhydrase, azopt prevents the build-up of pressure in the eyes due to ocular fluid retention. Continue reading...

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About the Drug

When the pressure in the eye is raised above the homeostatic levels, this could result in damage to the retina; the back of the eye which is sensitive to light and to the optic nerve; the nerve connecting the brain and eye. Therefore it is necessary to lower the pressure back to the normal eye pressure. Azopt does this by acting as a carbonic anhydrase inhibitor. Carbonic anhydrase is the enzyme responsible for producing bicarbonate ions and these ions are essential in the production of the fluid in the eye.


How to Take Azopt

Azopt is a prescription drug which is available as a clear suspension that can be used as an eye drop by patients with ocular hypertension or glaucoma. It is either used on its own or in combination with beta-blockers or other medications used for such eye conditions. It can also be a substitute treatment for patients who are unable to use beta-blockers. The usual recommended dose is one drop thrice daily on the affected eye. The container should be well shaken before use as the suspension may settle when left to stand. When used in combination with other eye drop, a 5 minute interval should be allowed between each drug.


Contraindications

People who are allergic to brinzolamide or other Azopt ingredients should no use this drug as well as those with severe kidney problems or problems caused by excessive chloride in the blood. Furthermore soft contact lenses will be discolored by Azopt therefore care must be taken by contact wearers while using this drug.


Possible Side Effects

Redness of the eye, blurred vision, fluid discharge from the eyes, inflammation of the eye lids, eye irritation, itching of the eyes, headache, dysgeusia, dry mouth and sensation of substances in the eyes.


Pregnant and Breastfeeding

Always inform your doctor before taking any medication during pregnancy or while breastfeeding as the consequent of the amplified effect on the child must be considered before deciding to take any medication. The consequence of taking this drug during pregnancy is not yet established therefore pregnant women should not use Azopt unless recommended by the doctor as crucial. Breastfeeding mothers should seek medical attention before using Azopt as it is uncertain if or not the drug is released in the breast milk.


 

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