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Boniva prescribing information

 



Boniva description

Boniva acts by inhibiting the activity of cells responsible for breakdown of bone tissue in the body; osteoclasts thereby reducing bone loss. Although studies have shown that Boniva can be effective in minimizing the risk spine fractures, its efficacy minimizing the risk of fractures in the neck and femur is yet to be established.

About Boniva
Osteoporosis is a condition where the bone is brittle and weakened as a result of constant bone tissue breakdown by the osteoclasts. People with this condition are more liable to bone fracture; this is most often post menopausal women due to the decreased level of the hormone oestrogen in this group. Boniva can be used to treat such condition by blocking the action of the osteoclasts cells, preventing them from breaking down the bones. The active ingredient which gives Boniva this property is the FDA approved Ibandronic acid which is a rather potent but effective drug component. This compound binds firmly to the bone protecting it from breakdown by the osteoclast. Decreasing the rate of bone breakdown also means a decrease in the calcium levels in the blood therefore people with hypercalciemia (high calcium concentration in blood) can also be treated with this drug.


How to Take Boniva
Boniva is available in the form of 150mg tablets to be taken orally alternatively it is also available for intravenous injection. It is recommended for people suffering from osteoporosis as well as those with hypocalcaemia. It is usually taken once in a month with a glass of water following an overnight fast and followed in an hour by food or drink which is not water. The tablet should be taken while the patient is in an upright (sitting or standing) position and should not be sucked; chewed or crushed rather it should be swallowed. While taking this medication, patients should consume enough vitamin D and calcium from diet or supplements. No other drug should be taken orally within 6 hours prior to taking this drug or within the hour after taking it.


Contraindication
Boniva should not be prescribed to people with: hypocalcaemia, loss of ability to stand or sit upright for a period of an hour at least, difficulty with swallowing or problems with the food pipe. It is also not to be prescribed to children, pregnant and breastfeeding women. People who are known to be hypersensitive to any ingredients in Boniva should not use this drug and once a person start to show signs of allergy the medication should be stopped.


Possible side effect
For oral doses, Boniva can result in ulceration and irritation in the oesophagus this can be decreased by adhering to the instructions for oral dosage carefully as mentioned above. Should you notice any problems with your food pipe stop taking the medicine and consult your doctor. This drug may cause a drop in the blood calcium which could be minimized by taking supplements. Osteonecrosis of the jaw is also likely to occur, especially in cancer patient. The tendency for this to occur could be reduced by maintaining good oral hygiene. Other side effects which are more likely to occur include Headache, stomach and gut upset, muscle cramps, rash, and difficulty with swallowing, flu type symptoms, musculoskeletal pain, inflammation of the stomach and food pipe ulceration or inflammation. Less common side effects include indigestion, nausea, vomiting, dizziness, back pain, flatulence and fatigue while duodenitis, bronchospasm, angioedema and itchy blistered rash are much rarer ones.


Pregnant and Nursing Mothers
This drug is not to be used in pregnant women or nursing mothers as this may cause harm to the child.


Boniva review article...

 

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Bone resorption inhibitor
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