CalciTrio Review Article
This innovative product has a combination of the three important nutrients in one single, easy to assume tablet in the form of CalciTrio, thus providing a convenient and more effective mean to manage bone health and other age related diseases. CalciTrio is a nutrient supplement which combines Calcium, Vitamin K2 and Vitamin D3.
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|Ca 500 mg, K2 45 mcg, D3 10 mcg
Calcium, Vitamin K and D for Healthier Bones and Longer Life
While vitamin D has been widely considered as one of the super vitamins, with health impact ranging from treatment of osteoporosis to management of diabetes, calcium is useful to strengthen bones and prevent teeth demineralization, while vitamin K usefulness is well known for blood coagulation. Recent studies have shown that combining these three nutrients could provide even more health benefits than when used individually. Researchers have predominantly studied the effect of this combination on bone health while some studies indicate potential of other health benefits. Bone is a mineralized tissue, a truly complex organic material, made up of various living structures composed by collagen fibers reinforcing and giving elasticity to a rigid matrix of calcium hydroxyapatite crystals. Bone also contains many living cells, mainly osteocytes and osteoclasts, whose function is, respectively, to build up new bone tissue, and resorb (recycle) it. As the body grows in the earlier stages of life the bones develops and strengthen themselves, in order to support the body for movement, protecting delicate organs such as the rib cage around the heart, and the skull containing the brain. At the later stage in life, as aging sets in, the bone might begin to degenerate in a process called osteoporosis, making the individual more susceptible to bone fractures. Proper formation and functioning of the bones is also linked with functioning of other organs and tissues in the body, for example bone marrow cells that are responsible for the production of the red blood cells.
A combination of calcium, vitamin K and Vitamin D have been shown to have significant effect of bone health in addition to other health benefits. Firstly let us look at the individual constituents of before we then discuss how their combination are beneficial to health.
Calcium is said to be the mineral found in the largest quantity in the body. It is important for various physiological activities such as transmission of messages across neurons and nerves through cell depolarization, secretion of hormones, blood vessels contraction and relaxation mechanisms, as well as general muscle contractility. A large proportion of the calcium in the body is used for formation of bones and teeth. The intake and release of bones for metabolic activities, bone and teeth formation maintains a tightly regulated calcium concentration in the body. Recommended daily allowance of calcium is about 1000mg for adult male and female between the age of 19 and 50. A higher amount of 1200mg is required by older women of age 51 and over. Other than bone and teeth formation, calcium also contributes to health by preventing osteoporosis, regulating blood pressure, promoting good cardiovascular functioning, reducing the risk factor for many types of cancer (colon, prostate and rectum), preventing kidney stones formation, and helping with weight management. A correct Calcium intake prevents cardiovascular diseases and helps in weight management by regulating the lipid absorption by the intestine and lowering cholesterol level.
Vitamin K is widely known as the vitamin responsible for blood coagulation in the body. It exists in many isoforms, called “vitamers”, of wich two of these forms, K1 and K2, are the most common. Vitamin K1 (also known as phytomenadione) although found in plants, can be ingested by animals, who convert it to the metabolically active K2 isoform through their colonic bacterial flora. Vitamin K2 is found in animals and can be further divided into several subtypes known as menaquinones denoted MK-n (where n could be any number ranging from 1 up to 11) with MK-4 being the most common form of vitamin K2. The different forms of vitamin K2 differ mainly in the length of residues in their side chains but they all possess similar physiological activity in vivo. Vitamin K has been linked with bone health as well as other conditions such as Alzheimer's disease, cancer and age related diabetes. It prevents Alzheimer’s by reducing nerve cells apoptosis (cell death), and protecting neurons from various kinds of damage. Preliminary studies also show a relationship between colon cancer and intake of vitamin K.
Vitamin D, also fondly known as the "sunshine vitamin", is a group of steroid compounds called secosteroids. They differ from the other vitamins as they are not classified as an essential nutrient since they can be synthesized by the human skin just through direct exposition to sufficient amounts of sunlight. Vitamin D regulates the uptake and metabolism of both calcium and phosphates in the human body. Vitamin D exists in various subtypes, the most important of which are D2 (ergocalciferol) and D3 (cholecalciferol). Vitamin D3 can be easily produced photochemically by the body, specifically in the dermis, under exposure to sunshine. D2 can be obtained from diet and supplements instead, and its deficiency is known to cause rickets. Furthermore its dietetic supplementation provides additional benefits, such as reduction in mortality rate in females from age 50 onward, and promotion of bones’ health. No recommendation has yet been made as to the specific amount of sunlight required for the body to synthesize the necessary amount of vitamin D, however meals and supplement containing vitamin D can be taken to meet the required amount. Vitamin D has been shown to prevent conditions such as osteoporosis, depression, diabetes, autism, cancer, eczema, muscle pain, asthma and septicdmia.
Vitamin D and Vitamin K
For bone formation, vitamin D works in synergy with vitamin K to increase bone mineral density and maintain calcium homeostatic balance, which is required to form new bone tissue, while repairing worn out bones. This process requires the carboxylation of a compound called osteocalcin. Presence of vitamin K aids in this process because its absence blocks osteocalcin in an undercarboxylated state, thus hindering adequate formation of bones. While vitamin K ensures proper bone formation, vitamin D ensures that the bones are formed in the right place. This is achieved by vitamin K regulating the entry of calcium while vitamin D ensures the proper placement.
Vitamin D and calcium
Studies in 2007 reported by the scientific journal Lancet, by a group of researchers at the centre for complementary medicine research, University of Western Sydney in new south Wales, Australia led by Tang BM provided evidence which show that combination of calcium and vitamin D supplement is effective in preventing and treating osteoporosis in elderly women at a concentration of 1200mg of calcium + 800IU of Vitamin D. The study was based on electronic data collected on 63897 patients with a minimum age of 50.
Vitamin K2, Vitamin D3 and calcium
As highlighted above, each nutrient provides health benefits when taken on its own and indeed taking each of these in a combined supplement form or through meals does provide cumulative health benefits. However, to obtain an optimum benefit, taking a combination of all three has proven even more effective, thanks to a synergic effect. A 6 months study involving 78 Korean women of age 60 and older show that the group with additional intake of vitamin k supplement alongside vitamin D and calcium showed increase in bone mineral density and decrease in undercarboxylated osteocalcin, compared to the group that took vitamin D and calcium only.
This innovative product has a combination of the three important nutrients in one single, easy to
assume tablet in the form of CalciTrio, thus providing a convenient and more effective mean to manage bone health and other related diseases. CalciTrio is a nutrient supplement which combines Calcium, Vitamin K2 and Vitamin D3. These are considered the three main nutrients necessary for attaining strong healthy bones. CalciTrio contains Calcium, vitamin K2 and Vitamin D3 in the ratio 500mg: 45µg: 10µg representing 63%, 60% and 200% of recommended daily allowance (RDA). CalciTrio comes in film coated tablet form and contains no gluten or lactose. For pregnant and nursing mothers the supplement should not be taken without consulting a medical expertise first. Similarly, subjects taking medications which affect blood coagulation should also seek medical advice before taking the supplement. Individuals suffering from soy allergy are advised against taking this supplement.
Bone resorption inhibitor
CalciTrio Review Article