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Campto Review Article

 

CamptoIrinotecan (brand name: Camptosar, manuf. by Pfizer; and barand name: Campto, manuf. by Yakult Honsha) is a drug used for the treatment of cancer. Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. In chemical terms, it is a semisynthetic analogue of the natural alkaloid camptothecin.

Its main use is in colon cancer, in particular, in combination with other chemotherapy agents. This includes the regimen FOLFIRI, which consists of infusional 5-fluorouracil, leucovorin, and irinotecan.

Camptosar’s active ingredient which is irinotecan hydrochloride has proved to be a powerful substance for cancer treatment. Camptosar may be used both alone or in combination with other anticancer medicines. Immediately after the spread of bowel cancer has been diagnosed Camptosar should be prescribed as a part of anticancer therapy. Campostar can be taken alone after cancer relapse. However it is important that a patient takes blood test to rule out the possibility of allergy to any components of the preparation.

Campto, also known as Camptosar is used in the treatment of bowel cancer, when it has already infested other organs and surgery alone cannot assure the desired result. For that reason, medication with anticancer drugs is indicated as alternatives, also known as chemotherapy. Continue reading...


The active ingredient of Camptosar is irinotecan hydrochloride, which is considered as powerful substance for the treatment of cancer. Sorbitol, lactic acid, sodium hydroxide and hydrochloric acid are other constituents of Camptosar. Camptosar is administered alone or given with other anticancer drugs soon after the spread of cancer beyond the bowel and can also be taken after cancer relapse.


Dosage

Camptosar is usually given by the doctor and the recommended dose is between 125 mg/m2 and 350 mg/m2 , depending on body surface area and the dosing schedule. The dose might be increased or decreased depending on your response.

The doctor dilutes and then slowly instils the drug into a vein over a period of 90 minutes. Depending on whether it is administered alone or along with other anticancer medicines, it is advised that it be giver in different treatment courses.

If given along with other anticancer medicines, the duration of treatment courses is 6 weeks and the medicine can be given on weekly basis or every fortnight. Around 1 to 2 weeks of rest is included in the course. However, the duration of treatment courses is of 4 weeks when Camptosar is given alone. In addition, a rest period of 2 weeks is given after completing this course. The medicine is given once in every 3 weeks’ period.

The treatment might be stopped if the patient experiences severe diarrhoea and other severe side effects. The treatment courses can be repeated as per the response of the patient.


Indications

Always consult your doctor, if you are taking prescription from a pharmacy, vitamin supplements or any other medicines like laxatives, diuretics, dexamethasone, anti-convulsants , St Johns Wort’s herbal medicines for depression and ketoconazole. Also, inform your doctor if you are taking medicines for nausea or diarrhoea.


Side effects

During or after the treatment with Camptosar, you might feel certain side effects like nausea, vomiting, diarrhoea, stomach cramping, anaemia, infections, weakness, hair loss, constipation, coughing, skin rash, dizziness, flatulence, sore mouth, heartburn, fever, weight loss, dehydration and difficulty in breathing or sleeping.

Diarrhoea is the most common side effect during the treatment with Camptosar and it can be life threatening if not treated timely. The doctor might indicate some other medicines before giving Camptosar to ensure that you do not vomit or feel sick.

Some rare symptoms associated with Campto are jaundice, increased risk of bleeding, severe fever with a reduction in white blood cell numbers, bleeding from the bowel, kidney problems, chest pains, heart attack, blackouts, swelling and redness along a vein and others.


Cautions and Precautions

You should not take Camptosar if you are allergic to irinotecan hydrochloride, pregnant or may become pregnant during the treatment, breast-feeding.

Before undergoing this treatment, you will have a blood test. Your doctor might give you antibiotics if you have insufficient white blood cells, which can also be known if you show certain symptoms like frequent infections such as fever, severe chills, sore throat or mouth ulcers.

It is advised that you speak to your doctor prior to the treatment if you are of or above 65 years of age and have or ever had liver problem, kidney or heart problems , diabetes , asthma, constipation, hereditary fructose intolerance or difficulty urinating. Moreover, tell your doctor, if you have ever undergone radiation therapy.

See also: Bowel and Stomach cancer


 

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