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Ciprobay prescribing information

 



Ciprobay description

Ciprobay is an anti bacterial synthetic drug that is also available in other brand names including Ciloxan, Cipro XR and Proquin. Ciprobay belongs to the medicinal group of quinolones that are also known as gyrase inhibitors. It is indicated to develop protection against the bacteria that divides within the human body, because it has the ability to violate the transcription of bacterial chromosomes that are required for a normal metabolism. This drug works by breaking the transcription of bacterial chromosomes that is vital for metabolism and division of bacteria.

The reason why people prefer Ciprobay is its ability fight against the bacteria that are resistant to other anti-biotic like aminoglycosides, enicillins, tetracyclines, cephalosporins and many others. It is because of this unique property, it is used for the treatment of different types of infections like that of urinary tract, respiratory tract and genital organs like adnexitis, gonorrhea and prostatitis, sinuses, infection of eye, abdominal, skin bones and even joints.

Description

Ciprobay is generally an anti bacterial drug, which is used for treating many infections caused in the human body by bacteria like pneumonia; gonorrhea; infectious diarrhea; typhoid fever, inhalational anthrax and bone, joint, skin, and urinary tract infections. Earlier on US Food and Drug Administration approved the medicine to be used on the patients who are affected with inhaled form of anthrax.

Dosage

Ciprobay medicine can be taken without or even without food because it is metabolized by the liver partially and rest excreted by kidney. Although the doses are normally the same but, it may differ in certain cases in which the patients have abnormal kidney or liver function.

Dosage Form

Cipro can be taken with or without food. Cipro is partially metabolized by the liver and the kidney excretes rest. Dosages require adjustment in patients with severely abnormal liver or kidney function.

Interactions

Since antacids have the capability of blocking the absorption process of Ciprobay, they should not be taken together. Ciprobay if consumed with theophylline can result in elevated level of the same in blood that can lead to seizures and even disturbance in rhythm of heart beats especially for people who are dealing with central nervous system diseases. There are chances that excess intake of Ciprobay may lead to the over growth of a bacteria, which is responsible for the inflammation of the colon. The bacteria is named as Pseudomembranous colitis, over growth of which can lead to problems like abdominal pain, fever, diarrhea and sometimes even shock.

Side effects

Some of the side effects of Ciprobay are problems of restlessness, pain in abdomen, diarrhea, vomiting and headache while some of the rare effects have been hives and sudden shock or anaphylaxis. People who are taking Ciprobay have the tendency to develop sensitive skin to direct sunlight and even increase the risk of bleeding.

Caution

It is advised to avoid consuming Ciprobay with dairy products like milk and yoghurt alone. Drinking a lot of caffeine with prescription may result in problems like nervousness, increase of heart beat rate and much more.


2010 Jul-Aug;67(4):345-9.
Kloskowski T, Olkowska J, Nazlica A, Drewa T.
Department of Tissue Engineering, Chair of Medical Biology, Nicolaus Copermicus University, Kar?owicza 24, 85-092 Bydgoszcz, Poland. tomaszkloskowski@op.plq

The influence of ciprofloxacin on hamster ovarian cancer cell line CHO AA8. [The effect of ciprofloxacin on cancerous cells of hamster ovarian]


2010:296034. Epub 2010 Jun 16.
De Benedetti G, Brancaccio A.
Hospital Quir?n Donostia, 7, Parque Alcolea, 20012 San Sebastian, Spain.

Corneal deposit of ciprofloxacin after laser assisted subepithelial keratomileusis procedure: a case report. [Substantial collection of ciprofloxacin when given subepithelial keratomileusis treatment]


2010 May 15. [Epub ahead of print]
De Bel E, Janssen C, De Smet S, Van Langenhove H, Dewulf J.
Research Group EnVOC, Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.

Sonolysis of ciprofloxacin in aqueous solution: Influence of operational parameters. [Effect of ciprofloaxcin in diluted solution with respect to working arena]


2009 Dec;28(3):1129-42.
Otero JL, Mestorino N, Errecalde JO.
C?tedra de Tecnolog?a de los Alimentos, Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, R.P. Kreder 2805, S3080HOF, Esperanza, Santa Fe, Argentina.

Pharmacokinetics of enrofloxacin after single intravenous administration in sheep. [Effect of enrofloxacin when administered in sheep]


2009 Aug;44(6):571-7.
Nannapaneni R, Chalova VI, Story R, Wiggins KC, Crandall PG, Ricke SC, Johnson MG.
Center for Food Safety-IFSE, University of Arkansas, Fayetteville, Arkansas, USA.

Ciprofloxacin-sensitive and ciprofloxacin-resistant Campylobacter jejuni are equally susceptible to natural orange oil-based antimicrobials. [Importance of ciprofloxacin to nature based antimicrobials]


2008 Dec;6(5):264-8.
Damuth E, Heidelbaugh J, Malani PN, Cinti SK.
University of Michigan Medical School, University of Michigan Health System, Ann Arbor, Michigan, USA.

An elderly patient with fluoroquinolone-associated achilles tendinitis. [Case history of an aged patient diagnosed with achilles tendinitis.]


2008 Sep;2(3):575-9.
Zhang C, Liang Y, Deng S, Wang Z, Li R, Sun X.
Department of Ocular Microbiology, Beijing Institute of Ophthalmology, Beijing Tongren hospital, Capital University of Medical Science, Beijing.

Distribution of bacterial keratitis and emerging resistance to antibiotics in China from 2001 to 2004. [Spreading of bacterial keratitis and avoidance to antibiotics in the state of China since 2001]


2008 Dec;41(6):507-12.
Lee HY, Yang YJ, Su LH, Hsu CH, Fu YM, Chiu CH.
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Genotyping and antimicrobial susceptibility of Salmonella enterica serotype Panama isolated in Taiwan. [Significance of Salmonella enterica serotype Panama in Taiwan]


2007 Jul;18(4):257-61.
Sztramko R, Katz K, Antoniou T, Mulvey M, Brunetta J, Crouzat F, Kovacs C, Merkley B, Tilley D, Loutfy MR.
Faculty of Medicine, University of Toronto.

Community-associated methicillin-resistant Staphylococcus aureus infections in men who have sex with men: A case series. [Homosexual case study : Community-associated methicillin-resistant Staphylococcus aureus infections]


2007 Nov;38(6):1095-101.
Sianglum W, Wonglumsom W, Srimanote P, Kittiniyom K.
Department of Clinical Microbiology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.

Analysis of gyrA mutations related to quinolone resistance in Escherichia coli isolates originating from pet, human, vegetable and ice in Bangkok and vicinity. [A case history on resistance on account of Escherichia coli isolates originating from pet


2007 Oct-Dec;5(4):497-500.
Yadav RP, Agrawal CS, Adhikary S, Kumar M, Regmi R, Amatya R, Gupta RK.
Department of Medicine, BP Koirala Institute of Health Science, Dharan, Nepal.

Iliopsoas abscess: analysis and perspectives from an endemic region of Eastern Nepal. [Distribution and view point of an endemic region of eastern Nepal]


2010 Jul-Aug;67(4):345-9.
Kloskowski T, Olkowska J, Nazlica A, Drewa T.
Department of Tissue Engineering, Chair of Medical Biology, Nicolaus Copermicus University, Kar?owicza 24, 85-092 Bydgoszcz, Poland.

The effect of ciprofloxacin on cancerous cells of hamster ovarian

The influence of ciprofloxacin on hamster ovarian cancer cell line CHO AA8.


2010;2010:296034. Epub 2010 Jun 16.
De Benedetti G, Brancaccio A.
Hospital Quir?n Donostia, 7, Parque Alcolea, 20012 San Sebastian, Spain.

Substantial collection of ciprofloxacin when given subepithelial keratomileusis treatment

Corneal deposit of ciprofloxacin after laser assisted subepithelial keratomileusis procedure: a case report.


2009 Aug;44(6):571-7.
Nannapaneni R, Chalova VI, Story R, Wiggins KC, Crandall PG, Ricke SC, Johnson MG.
Center for Food Safety-IFSE, University of Arkansas, Fayetteville, Arkansas, USA.

Importance of ciprofloxacin to nature based antimicrobials

Ciprofloxacin-sensitive and ciprofloxacin-resistant Campylobacter jejuni are equally susceptible to natural orange oil-based antimicrobials.


2008 Dec;6(5):264-8.
Damuth E, Heidelbaugh J, Malani PN, Cinti SK.
University of Michigan Medical School, University of Michigan Health System, Ann Arbor, Michigan, USA.

Case history of an aged patient diagnosed with achilles tendinitis

An elderly patient with fluoroquinolone-associated achilles tendinitis.


2008 Dec;41(6):507-12.
Lee HY, Yang YJ, Su LH, Hsu CH, Fu YM, Chiu CH.
Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Significance of Salmonella enterica serotype Panama in Taiwan

Genotyping and antimicrobial susceptibility of Salmonella enterica serotype Panama isolated in Taiwan.


2007 Jul;18(4):257-61.
Sztramko R, Katz K, Antoniou T, Mulvey M, Brunetta J, Crouzat F, Kovacs C, Merkley B, Tilley D, Loutfy MR.
Faculty of Medicine, University of Toronto.

Homosexual case study : Community-associated methicillin-resistant Staphylococcus aureus infections

Community-associated methicillin-resistant Staphylococcus aureus infections in men who have sex with men: A case series.


2007 Nov;38(6):1095-101.
Sianglum W, Wonglumsom W, Srimanote P, Kittiniyom K.
Department of Clinical Microbiology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.

A case history on resistance on account of Escherichia coli isolates originating from pet, human, vegetable and ice in Bangkok

Analysis of gyrA mutations related to quinolone resistance in Escherichia coli isolates originating from pet, human, vegetable and ice in Bangkok and vicinity.


JAMA, May 3, 2000; vol. 283, no. 17: 2281-2290.
Inglesby TV, Dennis DT, Henderson DA, et al.

Plague as a Biological Weapon: Medical and Public Health Management

A working group of 25 representatives from major academic medical centers and research, government, military, public health, and emergency management institutions and agencies developed consensus-based recommendations for measures to be taken by medical and public health professionals following the use of plague as a biological weapon against a civilian population. View full article

Pathogenesis and clinical manifestation of plague
The bacteria migrate through cutaneous lymphatics to regional lymph nodes where they are phagocytosed but resist destruction. They rapidly multiply, causing destruction and necrosis of lymph node architecture with subsequent bacteremia, septicemia, and endotoxemia that can lead quickly to shock, disseminated intravascular coagulation, and coma. Following a deliberate attack, aerosolized inhaled Y. pestis bacilli would cause primary pneumonic plague, with the time from exposure to the development of first symptoms being 1-6 days and, most often, 2-4 days.
Vaccination
No vaccine of proven efficacy against primary pneumonic plague exists. The U.S.-licensed, formaldehyde-killed whole bacilli vaccine was discontinued by its manufacturers in 1999; this killed vaccine did not prevent or ameliorate the development of primary pneumonic plague.
Mass Casualty Setting and Postexposure Prophylaxis
Adults Preferred choices: Doxycycline, 100 mg orally twice daily. Ciprofloxacin, 500 mg orally twice daily. Alternative choices: Chloramphenicol, 25 mg/kg orally 4 times daily. View full article


Can J Microbiol. 2007 Jan;53(1):144-147.
Adjei MD, Heinze TM, Deck J, Freeman JP, Williams AJ, Sutherland JB

Acetylation and nitrosation of ciprofloxacin by environmental strains of mycobacteria.

Environmental strains of mycobacteria can be determined by Acetylation and nitrosation of ciprofloxacin.


Drug Metab Pharmacokinet. 2007 Apr;22(2):88-95.
Chono S, Tanino T, Seki T, Morimoto K.
Department of Pharmaceutics, Hokkaido Pharmaceutical University.

Pharmacokinetic and pharmacodynamic efficacy of intrapulmonary administration of ciprofloxacin for the treatment of respiratory infections.

The treatment of respiratory infections are based on the Pharmacokinetic and pharmacodynamic efficacy of intrapulmonary administration of ciprofloxacin.


J Trace Elem Med Biol. 2007;21(2):132-7.
Zaghloul IY, Radwan MA, Aly ZH.
Department of Clinical Pharmacy, College of Pharmacy, PO Box 22452, Riyadh 11495, Saudi Arabia.

The effect of chronic cadmium exposure on the pharmacokinetics of theophylline and ciprofloxacin in rats.

Efficacy of chronic cadmium exposure on the pharmacokinetics of theophylline and ciprofloxacin in rats.


Infect Control Hosp Epidemiol. 2006 Oct;27(10):1088-95.
Zillich AJ, Sutherland JM, Wilson SJ, Diekema DJ, Ernst EJ, Vaughn TE, Doebbeling BN.
Department of Pharmacy Practice, Purdue University College of Pharmacy, West Lafayette, Indiana, USA.

Antimicrobial Use Control Measures to Prevent and Control Antimicrobial Resistance in US Hospitals.

Control measures to prevent antimicrobial resistance in US Hospitals.


J Infect Chemother. 2005 Feb;11(1):52-4.
Okimoto N, Yamato K, Honda Y, Kurihara T, Osaki K, Asaoka N, Fujita K, Ohba H.
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School Kawasaki Hospital, 2-1-80 Nakasange, Okayama, 700-0821, Japan.

Clinical effect of intravenous ciprofloxacin on hospital-acquired pneumonia.

Efficacy of intravenous ciprofloxacin for the treatment of acquired pneumonia.


J Antimicrob Chemother. 2005 Feb 24; [Epub ahead of print]
Seral C, Barcia-Macay M, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F.
Unite de pharmacologie cellulaire et moleculaire, Universite catholique de Louvain, Brussels, Belgium.

Comparative activity of quinolones (ciprofloxacin, levofloxacin, moxifloxacin and garenoxacin) against extracellular and intracellular infection by Listeria monocytogenes and Staphylococcus aureus in J774 macrophages.

Effect of quinolones such as ciprofloxacin, levofloxacin, moxifloxacin and garenoxacin, against extracellular and intracellular infection by Listeria monocytogenes and Staphylococcus aureus in J774 macrophages.


J Antimicrob Chemother. 2005 Feb 24; [Epub ahead of print]
Steward J, Piercy T, Lever MS, Nelson M, Simpson AJ, Brooks TJ.
Biomedical Sciences, Dstl Porton Down, Salisbury SP4 OJQ, UK.

Comparison of gatifloxacin, moxifloxacin and ciprofloxacin for treatment of experimental Burkholderia pseudomallei infection.

Treatmant for experimental Burkholderia pseudomallei infection using gatifloxacin, moxifloxacin and ciprofloxacin.


Harefuah 2002 May;141 Spec No:63-72, 121, 120
Mozes YN, Winder A, Tadmor B, Rotman E, Sagi R, Hourvitz A
Childrens Ward A, Schneider Childrens Medical Centre, Israel

Anthrax - an overview at 2002

An overview of Anthrax in 2002.


Nihon Kokyuki Gakkai Zasshi. 2003 Mar;41(3):211-8.
Sasaki E, Kaida H, Izumikawa K, Izumikawa K, Hara K, Hirakata Y, Tomono K, Kohno S.
Department of Internal Medicine, Izumikawa Hospital.

Two cases of Legionella pneumophila pneumonia improved by parenteral ciprofloxacin administration.

Parenteral ciprofloxacin administration for the legionella pneumophila pneumonia saved two patients.


Intern Med. 2003 Apr;42(4):318-21.
Ishikawa T, Okamura S, Oshimoto H, Kobayashi R, Mori M.
First Department of Internal Medicine, Gunma University, Maebashi.

Metronidazole plus ciprofloxacin therapy for active Crohn's disease.

Treatment for Crohn's disease using metronidazole plus ciprofloxacin therapy.


Scand J Infect Dis. 2003;35(1):34-9.
Ulleryd P, Sandberg T.
Department of Infectious Diseases, Sahlgrenska University Hospital, Goteborg, Sweden.

Ciprofloxacin for 2 or 4 weeks in the treatment of febrile urinary tract infection in men: a randomized trial with a 1 year follow-up.

A randomized trial with a 1 year follow-up on the treatment of febrile urinary tract infection in men using ciprofloxacin for 2 or 4 weeks.


Antibiot Khimioter. 2002;47(10):3-7.
Duisenova AK, Kurmanova KB, Kurmanova GM.
Scientific Center of Hygiene and Epidemiology, Almaty State Institute of Prolonged Education, Republik of Kazakhstan, Almaty.

Ciprofloxacin in the treatment of patients with brucellosis.

Treatment for patients affected with brucellosis using Ciprofloxacin.


Int J Oncol. 2003 Apr;22(4):787-94.
Aranha O, Grignon R, Fernandes N, McDonnell TJ, Wood DP Jr, Sarkar FH.
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA.

Suppression of human prostate cancer cell growth by ciprofloxacin is associated with cell cycle arrest and apoptosis.

Ciprofloxacin can suppress the growth of human prostate cancer cell linked with cell cycle arrest and apoptosis.


Clin Infect Dis. 2003 Feb 15;36(4):521-3. Epub 2003 Jan 29.
Kuberski T, Robinson L, Schurgin A.
John C. Lincoln Hospital-Deer Valley, Phoenix, AZ, USA.

A case of plague successfully treated with ciprofloxacin and sympathetic blockade for treatment of gangrene.

A successfully treatment of plague with ciprofloxacin and the treatment of gangrene uisng sympathetic blockade.


Pneumologie. 2002 Oct;56(10):599-604.
Kljucar S, Rost KL, Landen H.
DRK-Kliniken Westend, Zentrale Abteilung fur Anasthesiologie und Intensivmedizin, Berlin, Germany.

Ciprofloxacin in the treatment of hospital-acquired pneumonia: a surveillance study in 676 patients.

A surveillance study in 676 patients on the treatment of hospital-acquired pneumonia using Ciprofloxacin.


J Infect Chemother. 2001 Dec;7(4):255-7.
Takahashi S, Hirose T, Satoh T, Kato R, Hisasue SI, Takagi S, Shimizu T, Kunishima Y, Matsukawa M, Itoh N, Tsukamoto T.
Department of Urology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo-ku, Sapporo 060-8543, Japan.

Efficacy of a 14-day course of oral ciprofloxacin therapy for acute uncomplicated pyelonephritis.

Effect of oral ciprofloxacin therapy, a 14-day course, for the treatment of acute uncomplicated pyelonephritis.


Inflamm Bowel Dis. 2001 Nov;7(4):301-5.
Shen B, Achkar JP, Lashner BA, Ormsby AH, Remzi FH, Brzezinski A, Bevins CL, Bambrick ML, Seidner DL, Fazio VW.
Center for Inflammatory Bowel Disease, Department of Gastroenterology, The Cleveland Clinic Foundation, Ohio 44195, USA.

A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.

Acute pouchitis can be treated using ciprofloxacin and metronidazole: A randomized clinical trial.


Ciprobay review article...

 

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