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Coaxil Review Article

 

antidepressantsCoaxil (tianeptine), known also as Stablon is an antidepressant from a group of tricyclic derivatives. It accelerates uptake of serotonin by neurons in the cerebral cortex and hippocampus. According to the influence of the drug on mood disorders Coaxil occupies in the intermediate position between sedative and stimulant antidepressants. Taking of Coaxil results in decrease of somatic symptoms (such as pain in the epigastric region, nausea, dizziness, headache, palpitations, hot flashes, muscle aches). Coaxil normalizes the behavior and has positive impact on the behavior of the patients with chronic alcoholism during abstinence. The drug has no negative influence on memory, sleep and ability to concentrate. It also has no anticholinergic effects and is not addictive. Derived from various reasons, depression causes a wide range of symptoms that may leave many undesirable consequences. Continue reading...

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Coaxil pharmadynamic

Belonging in the class of Serotonin reuptake accelerators (opposite to the SSRIs - selective Serotonin reuptake inhibitors), Coaxil has a neurochemical profile that increases the Serotonin levels in brain, leading to a reduction in stress and anxiety.


CoaxilSerotonin is a monoamine neurotransmitter of the brain (there are 3 kinds of neurotransmitters: the Amino acids as glutamate, aspartate, D-serine, ¦?-aminobutyric acid, glycine; the Monoamines and other Biogenic amines as dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), histamine, Serotonin; and the Others as acetylcholine, adenosine, nitric oxide), which plays an essential part in regulating certain mental conditions: cognition, moods, feelings, attention, sleep, memory and reaction abilities. Due to the direct actions on the reuptake of Serotonin, Coaxil appears to have more effective advances on reducing unpleasant conditions of brain.


CoaxilUnlike other old antidepressant agents (amitriptyline, imipramine and fluoxetine), Coaxil (or Tianeptine) has a novel structure (a long lateral chain grafted on to a substituted dibenzothiazepin nucleus) and an efficacy (increasing instead of decreasing the reuptake of Serotonin in rat??s and human??s brain?? synaptosomes platelets). Tianeptine has the effect of reducing the hypothalamic-pituitary-adrenal response to stress, agitating behavioral deficiencies that are stress-induced, and eventually lead to measurable enhancement in antidepressant efficacy in short term (3 months) and long term (up to 1 year and longer) use. The incidence of dry mouth (38 vs. 20%), constipation (19 vs. 15%), dizziness/syncope (23 vs. 13%), drowsiness (17 vs. 10%) and postural hypotension (8 vs. 3%) are greater with amitriptyline than with Tianeptine.


Insomnia and night-mares occur more regular in Tianeptine than Amitriptyline recipients (20 vs. 7%). Particularly, the research in Tianeptine interactions and efficacy in cardiovascular and/or alcohol withdrawal patients that have profound reactions to the negative effects of psychotropic drugs, has reported the same efficient values with few or no adverse effects. This makes Tianeptine especially suitable for the elderly and people with alcohol withdrawals (Wilde and Benfield, 1995).


Coaxil dosage


Tianeptine can be used for short term (3 months) and long term (up to 1 year and longer) with low propensity of abuse (Wagstaff et al., 2001). In addition, discontinuation of tianeptine has not caused relapse or recurrence including withdrawal syndrome, and no deaths from overdosage have been reported. (Wilde and Benfield, 1995).

Due to direct actions to brain activities and the hormones regulation of Tianeptine, individuals should not use it for serious therapy without being under accurate observation by doctors. Any changes and/or uncertain symptoms occurring during the course of Tianeptine are highly recommended to be reported to specialists.


Coaxil side effects

Drugs like Coaxil (Tianeptine) can be transported through placenta. Pregnant women are highly recommended to not use, due to the fact that Tianeptine can leave abnormalities in gestation and harmfully affect the baby.


Among these undesirable consequences, anticholinergic effects (Anticholinergic agent blocks the neurotransmitter Acetylcholine in the central and the Peripheral nervous system and it can cause Gastrointestinal disorders, Respiratory disorders, Insomnia and Parkinson disease) accompanied with Hepatoxicity (the Hepatic toxicity ?C the situation of liver damage because of inappropriate use of chemical drugs and other substances) can be seen as the most serious cases but they rarely happen.


The elderly and alcohol withdrawal patients who are under a weights-loss course are sensitive users that are highly recommend to ask doctors before using Tianeptine and should take serious tests about their health and function before getting involve in the use of Tianeptine.


REFERENCES
L?¦pine, J.-P., Gastpar, M., Mendlewicz, J., and Tylee, A. 1997. Depression in the community: The first pan-European study DEPRES (Depression Research in European Society). Int Clin Psychopharmacol 12(1): 19-29.
Tylee, A., Gastpar, M., L?¦pine, J. -P., and Mendlewicz, J. 1999. DEPRES II (Depression Research in European Society II): a patient survey of the symptoms, disability and current management of depression in the community. Int Clin Psychopharmacol 14(3): 139-151.
Wagstaff A.J., Ormrod D., and Spencer C.M. 2001. Tianeptine: A Review of its Use in Depressive Disorders CNS. Drugs 15 (3): 231-259.
Wilde M. I., and Benfield P. 1995. Tianeptine: a review of its pharmacodynamics and pharmacokinetic properties, and therapeutic efficacy in depression and coexisting anxiety and depression. Drugs 49 (3): 411-439.


 

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