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Coverex prescribing information

 



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Coverex description

Coverex is a medicinal drug that falls in the category of ACE inhibitor. It consists of Angiotensin II, which is a chemical that causes the blood vessels to narrow by contracting the muscles surrounding it. It is due to the narrowing of the blood vessels that result in increase of blood pressure and decrease in hypertension. The angiotensin-converting enzyme (ACE) in blood coverts angiotensin I in to angiotensin II and it is the function of the ACE inhibitors to slow down these conversions so that the blood pressure is reduced with the enlargement of blood vessels. Other than that, it makes it easy for the heart to pump blood to all the body parts, thereby reducing the chances of heart failures and kidney diseases too.

Coverex falls in the category of ACE inhibitors that have the main function of reducing the activity of ACE, which results in the formation of angiotensin I and angiotensin II in the blood vessels. It is because of these chemicals the muscles around the blood vessels contract resulting in the narrowing of blood vessels. The narrowing of blood vessels results in hypertension and high blood pressure in patients. Because of the narrowed blood vessels, the heart in human body becomes over-burdened and the condition becomes worse. The elevated level of blood pressure results in the progress of other major problems like kidney failure and diabetes.

Interactions
ACE inhibitors like Coverex do have certain interactions with other medicinal drugs like the latter leads to increase in the potassium levels in human body that is why intake of potassium supplements, salt supplements or any other medicines that increases potassium in blood is prohibited. ACE inhibitors also have the tendency of increasing the blood concentration of lithium, also known as Eskalith that can lead to increased side effects. As per the studies, other medicinal drugs like Aspirin amd other anti-inflammatory drugs like ibuprofen, indomethacin, and naproxen reduce the functioning of ACE inhibitors. However, it may not be necessary in case of every human being.

Side effects
The ACE inhibitors like coverex do not have many side effects on all humans but they have certain side effects on some of the patients. Women who are about to deliver or are pregnant should not consume Coverex as they can lead to birth defects in child. Those who are already dealing with severe kidney trouble should avoid consumption of Coverex; same is the case with people who are allergic to ACE Inhibitors.

Other common side effects of Coverex are:
Cough Elevated levels of potassium in blood Low blood pressure Dizziness Weakness Abnormal change in the sense of taste Formation of rashes in body

If anyone is facing the problem of cough then it may take some time for him or her to get better. Apart from the common problems mentioned above, Coverex might result in severe problems like kidney failures, serious allergic reactions, decrease in count of white blood cells and a problem of angiodema, which results in the swelling of tissues in body.




Coverex is an ACE inhibitor

What are ACE inhibitors, and how do they work?
Angiotensin II is a very potent chemical that causes the muscles surrounding blood vessels to contract and thereby narrows the blood vessels. The narrowing of the vessels increases the pressure within the vessels and can cause high blood pressure (hypertension). Angiotensin II is formed from angiotensin I in the blood by the enzyme, angiotensin converting enzyme (ACE). ACE inhibitors are medications that slow (inhibit) the activity of the enzyme, which decreases the production of angiotensin II. As a result, the blood vessels enlarge or dilate, and the blood pressure is reduced. This lower blood pressure makes it easier for the heart to pump blood and can improve the function of a failing heart. In addition, the progression of kidney disease due to high blood pressure or diabetes is slowed.

For what conditions are ACE inhibitors used?
ACE inhibitors are used for controlling blood pressure, treating heart failure and preventing kidney damage in people with hypertension or diabetes. They also benefit patients who have had heart attacks. In studies, individuals with hypertension, heart failure, or prior heart attacks who were treated with an ACE inhibitor lived longer than patients who did not take an ACE inhibitor. Because they prevent early death resulting from hypertension, heart failure or heart attacks, ACE inhibitors are one of the most important group of drugs. Some individuals with hypertension do not respond sufficiently to ACE inhibitors alone. In these cases, other drugs are used in combination with ACE inhibitors.

Are there any differences among the different types of ACE inhibitors?
ACE inhibitors are very similar. However, they differ in how they are eliminated from the body and their doses. Some ACE inhibitors need to be converted into an active form in the body before they work. In addition, some ACE inhibitors may work more on ACE that is found in tissues than on ACE that is present in the blood. The importance of this difference or whether one ACE inhibitor is better than another, has not been determined.

What are the side effects of ACE inhibitors?
ACE inhibitors are relatively well-tolerated by most individuals. Nevertheless, they are not free of side effects, and some patients should not use ACE inhibitors. ACE inhibitors usually are not prescribed for pregnant patients because they may cause birth defects. Individuals with severe kidney problems and people who have had a severe reaction to ACE inhibitors probably should avoid them. The most common side effects are cough, elevated blood potassium levels, low blood pressure, dizziness, headache, drowsiness, weakness, abnormal taste (metallic or salty taste), and rash. It may take up to a month for coughing to subside, and if one ACE inhibitor causes cough it is likely that the others will too. The most serious, but rare, side effects of ACE inhibitors are kidney failure, allergic reactions, a decrease in white blood cells, and swelling of tissues (angioedema).

With which drugs do ACE inhibitors interact?
ACE inhibitors have few interactions with other drugs. Since ACE inhibitors may increase blood levels of potassium, the use of potassium supplements, salt substitutes (which often contain potassium), or other drugs that increase the body's potassium may result in excessive blood potassium levels. ACE inhibitors also may increase the blood concentration of lithium (Eskalith) and lead to an increase in side effects from lithium. There have been reports that aspirin and other non-steroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen, indomethacin, and naproxen may reduce the effects of ACE inhibitors; however, there is no conclusive evidence that this interaction, if it exists, is important.

What ACE inhibitors are available?
The following is a list of the ACE inhibitors that are available in the United States: captopril (Capoten), benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril) fosinopril Monopril), ramipril (Altace), perindopril (Coverex), quinapril Accupril), moexipril (Univasc), and trandolapril (Mavik).




Coverex notes

Coverex is the product brand name given to the drug Perindopril, which is an ACE inhibitor. Drugs like Coverex, which help in slowing down the production of angiotensin converting enzyme (ACE), are helpful for people suffering from hypertension and high blood glucose levels. The drug helps the patients by keeping a check on high BP, treating heart failure and also avoiding any damage to the kidneys. Coverex has also proven to be quite beneficial for patients who have already suffered from heart attack.

An ACE inhibitor like, coverex, help in reducing the activity of ACE, which if uncontrolled results in the formation of angiotensin I. Angiotensin I further produces a very powerful chemical called Angiotensin II, in the blood vessels. This chemical causes the contraction of the muscles that surround the blood vessels. As a result the blood vessels become narrower and this in turn causes the pressure to increase within the blood vessels, which finally gives rise to hypertension in the patient.

Coverex helps reduce the production of Angiotensin II, which avoids the possibility of the blood vessels narrowing down and causing high BP. This in turn enhances the functioning of the heart, which would otherwise be in a bad condition due to being overworked. Coverex also hinders the progress of ailments like kidney failure and diabetes, which are boosted by high blood pressure levels. Although Coverex has been found to be relatively safe for most patients, it is not free of some side effects. Pregnant women should absolutely refrain from taking this drug as it might result in some sort of birth defects. Also, people, who are suffering from serious kidney aliments or are allergic to ACE inhibitors, should not be given this drug. The other temporary side effects of Coverex include cough, high levels of blood potassium, low BP, dizziness, headache, drowsiness, weakness, abnormal taste and rashes.


Am Heart J. 2007 Apr;153(4):629-35.
Fox KM et all.

Risk of cardiac events in patients with revascularized coronary artery disease.

Perindopril can reduce the risk of cardiac events in patients with revascularized coronary artery disease.


Vasc Health Risk Manag. 2006;2(2):117-24.
Campbell DJ.

Perindopril in the reduction of cardiovascular events.

Perindopril is capable to reduce cardiovascular events: a review


Expert Opin Pharmacother. 2007 Apr;8(6):881-9.
Metra M et all.

World Congress of Cardiology 2006.

Information on trials clinical trials update from the World Congress of Cardiology held in 2006.


J Renin Angiotensin Aldosterone Syst. 2007 Mar;8(1):13-22.
Donnelly R, Manning G.
Derby City General Hospital, Derby, DE22 3DT, UK.

Angiotensin-converting enzyme inhibitors and coronary heart disease prevention.

Prevention of coronary heart disease and the Angiotensin-converting enzyme inhibitors.


Neurobiol Learn Mem. 2006 Sep 29;
Jenkins TA, Chai SY.
.

Angiotensin converting enzyme inhibition on spatial memory

Efficacy on spatial memory and anxiety-like behaviours in rats due to the chronic angiotensin converting enzyme inhibition.


Clin Ther. 2003 Jul;25(7):2006-21
Derosa G et all.

Perindopril and candesartan in hypertensive patients

Usage of perindopril vs candesartan in hypertensive patients with type 2 diabetes: a randomized, double-blind, controlled, parallel-group comparison study.


Lancet. 2003 Sep 6;362(9386):782-8.
Fox KM

Perindopril in reduction of cardiovascular disease, Clinical study

Perindopril is capable to reduce cardiovascular events in patients with stable coronary artery disease: a randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study).


Expert Rev Cardiovasc Ther. 2005 Jan;3(1):15-29.
Ferrari R.

Evidence with perindopril on angiotensin-converting enzyme inhibition in patients with cardiovascular disease.


Coverex review article...

 

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