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Cycloastragenol (TA-65 active substance) Review Article

 

Cycloastragenol (main ingredient in TA-65) is a clinically-proven telomerase activator, naturally-occurring single molecule extracted from the root of an herb. TA-65 adds back base pairs of telomeric DNA that have been lost in the aging process. This lengthening of telomeres protects chromosomes from damage, essentially protecting the cells where telomerase is activated from age-related decline.
What is TA-65? And why use such a code name? From Geron's patent document, it is clear that that cycloastragenol and Astragaloside IV are proved to be effective in lengthening the telomere. The question is: why Geron did not disclose what is the most effective ingredient in TA-65? The thoughtful and knowledgeable guess is that the magic ingredient is a natural molecule which can not be patented. Many reference and discussions also prove that the active ingredient of TA-65 is cycloastragenol at 98% purity. TA-65's dosage varies from 1 to 4 capsules daily. Telomerase activation Sciences,Inc. (T.A. Sciences) is the only company to dedicate its researchand development exclusively to telomeraseactivation. T.A. Sciences was founded by Noel Thomas Patton in 2002 with the express purpose of prolonging the human healthspan by extending telomeres. TA-65 provides a unique solution to the problem of shortening telomeres as the only telomerase activating product that is scientifically proven to lengthen short telomeres and rejuvenate aging cells.

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Cycloastragenol 98 % (purity) is the active ingredient in the telomerase activator (TA-65) recommended by anti-aging treatment. This ingredient is the only ingredient proven clinically to assist in Telomere lengthening.

Taking Astragaloside IV or Cycloastragenol supplements to extend telomeres was possibly a good anti-aging intervention.

Stimulating telomerase and increasing telomeres are without doubt the most promising ways of increasing life expectancy naturally. Animal and in vivo tests show that cycloastragenol is one of the very few substances - and the most powerful - that can appreciably increase such activity.

Cycloastragenol is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is extracted and purified from the root of the plant Astragalus membranaceus, which has been used in Chinese pharmacopaeia for thousands of years, particularly for its ability to slow down age-related degenerative processes. However, cycloastragenol is present in astragalus in minute quantities and extracting it is a highly complex and costly business.

Cycloastragenol has a similar chemical structure to that of the Astragaloside IV molecule, but it is smaller and significantly more bioavailable, enabling lower doses to be taken. It is already used as an immunostimulant because of its ability to increase T lymphocyte proliferation. However, it is its exceptional anti-aging properties that are of increasing interest to the scientific community. Cycloastragenol stimulates the repair of DNA damage by activating telomerase, a nucleoprotein enzyme which catalyses synthesis and growth of telomeric DNA. Telomeres are made of thin filaments and are found at the tips of chromosomes. Maintaining their stability enables cells to avoid replicative senescence and indefinite proliferation beyond the ‘Hayflick limit'. Telomeres shorten with each cycle of cell division, or when subjected to oxidative stress. Until now, this has been an unavoidable mechanism of aging.

Stimulating telomerase maintains telomere length

Recent studies have shown that shortened telomeres are responsible for a number of age-related diseases and are also predictive of premature death in elderly subjects. This has been confirmed by examining the immune response of T lymphocytes in terminal-phase infection, the T lymphocytes having significantly shortened telomeres. The study showed a noticeable fall in immune function and increased secretion of various cytokine-related pro-inflammatory factors. In contrast, maintaining a high telomerase level, whether through genetic manipulation or through the introduction of activating substances (such as cycloastragenol), curtails shortening of telomeres and even increases their numbers, restoring a more youthful T lymphocyte profile.

Cycloastragenol can be combined with Astragaloside IV, to provide a wider spectrum of activity, or it can be alternated with it.


 

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