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Hypertension

 

Hypertension, commonly known as high blood pressure, where the arterial pressure is elevated above the normal range expected in a particular age group. It may be of unknown cause (hyperpiesia) or it may result from kidney disease, narrowing of the renal artery (renal hypertension), endocrine diseases or disease of the arteries (symptomatic hypertension). Complications that may arise from it are atherosclerosis, heart failure, cerebral hemorrhage, and kidney failure, but treatment may prevent their development. Hypertension does not show symptoms until the symptoms of its complications develop. Most cases of hypertension depend upon long-term drug therapy to lower the blood pressure and maintain it low. Most common drugs used in the treatment of hypertension are thiazide diuretics, methyl-dopa, guanethidine and propranolol.

Products: Hypotensive agents

Accupril
HypertensionAccupril (Generic Name: quinapril) belongs in a class of drugs termed angiotensin converting enzyme or ACE inhibitors. Quinapril is used for treating high blood pressure or hypertension and for managing heart failure as an adjunctive therapy. ACE inhibitors are also used as a remedy in case of heart failure or hypertension but may also be used to prevent kidney failure caused by hypertension and diabetes. Side effects of quinapril may include coughing, vomiting, diziness, upset stomach, fatigue and angioedema.

Characteristics of Accupril in hypertensive patients.
Accupril is a brand name for the generic drug Quinapril which is a group of drugs that inhibits angiotensin converting enzyme. It is a commonly used maintenance for hypertension and medication for heart failure or diseases. This drug is taken in orally and will be converted to quinaprilat as an active metabolite once it reaches the liver. ACE is an essential enzyme that allows the conversion of Angiotensin I into Angiotensin II. Continue reading...


Adalat
AdalatAdalat (generic name: nifedipine) is a dihydropyridine calcium channel blocker. It is primarily used as an antihypertensive and antianginal (especially in the case of Prinzmetalís angina). Recently, a wide array of other uses of this drug has been discovered, such as premature labor, Raynaudís phenomenon, and painful contractions of the esophagus in tetanus and cancer patients. It is also widely used for a small division of pulmonary hypertension patients with symptoms responding to calcium channel blockers.

Adalat is classified as a dihydropyridine calcium channel blocker used as an antianginal for conditions such as Prinzmetalís angine as well as a antihypertensive. After some recent time, it has also been experimentally prescribed with premature labor, Raynaudís phenomenon and muscle spasms as exhibited with esophageal cancer or tetanus. On some cases, doctors prescribe Adalat to be used for pulmonary hypertension which affects respiratory capacity. The continued use is determined through any observable improvements in breathing or elimination of dizziness and other associated symptoms.


Avapro
AvaproAvapro (Generic Name: Irbesartan) is used for the treatment of high blood pressure. It belongs to the new class of drugs termed Angiotensin II receptor antagonists. This drugs mechanism is to inhibit the hormone Angiotensin II which works to narrow the blood vessels and results in high blood pressure. It is also recommended to ward off damage to the kidneys of people suffering from Type 2 Diabetes Mellitus, usually setting back the need for kidney transplant and dialysis. Avapro may be taken by itself or with other drugs for treating high blood pressure. Side effects may include flushing, dizziness, edema, headache, nausea, abnormal urination, libido changes, tachycardia, and diarrhea while contraindications include hypersensitivity, severe renal impairment, pregnancy, and lactation. Continue reading...


Benicar
 Fig 1. Blood pressure - the force exerted by the blood against the arteries Benicar (Generic Name: Olmesartan Medoxomi) is an antagonist of Angiotensin II receptor and is prescribed for people suffering from hypertension. It may be used as a first-line medication and may be utilized by itself or with other anti-hypertensive agents. On the other hand, Benicar HCT merges hydrochlorothiazide or HCTZ with Benicar. HCTZ is a thiazide diuretic. The combination in Benicar HCT provides much greater reduction in blood pressure. The combination of the two drugs is shown to have a complementary effect in decreasing the blood pressure. Side effects of Benicar may include dizziness while contraindications include pregnancy and Biliary obstruction. BENICAR AND BENICAR HCT MUST NOT BE USED DURING PREGNANCY. IT CAN CAUSE INJURY AND DEATH TO THE GROWING FETUS.

Hypertension

Blood pressure is defined as the force exerted by the blood against artery walls as it is being pumped by the heart (National Institute of Health). It is measured through two values Ė the systolic blood pressure and the diastolic blood pressure, which represents the force on the arteries as the heart contracts and relaxes to pump out blood. Continue reading...


Coverex
hypertensionCoverex is an ACE inhibitor. Angiotensin II is very potent chemical that causes the muscles surrounding the blood vessels to contract and so doing it narrows the blood vessels. Consequently, when blood vessels get narrowed, it increases your blood pressure and turns down to Hypertension. Angiotensin II is formed from angiotensin I in the blood by the enzyme, angiotensin converting enzyme (ACE). ACE inhibitors are medications that slow (inhibit) the activity of the enzyme, which decreases the production of angiotensin II. As a result, when blood vessels enlarge or dilate, the blood pressure is reduced. At this stage, it makes easier for the heart to pump blood normally and in contrast it prevents from heart failure diseases. Thus, the rampant and raging of kidney disease due to high blood pressure or diabetes is slowed and getting prevented.

Coverex (Perindopril erbumine) and hypertension

In recent time, World Health Organization (WHO) has confirmed that high blood pressure (Hypertension) and Diabetes appeared to be two of the most dangerous disease, especially to elders and individuals who have kidney problems. Global statistic records that 72 million - or one in three adults - have high blood pressure. Prevalence rates are steadily rising, from a rate of 25%, or 50 million adults, between 1988 and 1994 to 29%, or 65 million people by 2002 (U.S. Government data); Continue reading...


Coversyl
Sustained elevation of systolic and diastolic blood pressure
Coversyl is an ACE inhibitor. Angiotensin II is very potent chemical that causes the muscles surrounding the blood vessels to contract and so doing it narrows the blood vessels. Consequently, when blood vessels get narrowed, it increases your blood pressure and turns down to Hypertension. Angiotensin II is formed from angiotensin I in the blood by the enzyme, angiotensin converting enzyme (ACE). ACE inhibitors are medications that slow (inhibit) the activity of the enzyme, which decreases the production of angiotensin II. As a result, when blood vessels enlarge or dilate, the blood pressure is reduced. At this stage, it makes easier for the heart to pump blood normally and in contrast it prevents from heart failure diseases. Thus, the rampant and raging of kidney disease due to high blood pressure or diabetes is slowed and getting prevented.


Cozaar
high blood pressure measurementsCozaar is used to treat high blood pressure and it is effective when it is used alone or in combination with other high blood pressure medications, such as diuretics that help the body get rid of water. It is also used to slow the progress of kidney disease caused by type 2 diabetes, which do not require insulin shots.

Cozaar is a medicinal drug that is used for the treatment of high blood pressure. Cozaar is said to be more beneficial when used with other high blood pressure medication or simply used alone, for example Cozaar is used with diuretics in order to reduce the level of water in the human body. In general, the purpose of Cozaar is slow down the development of kidney problems that is caused due to type two diabetes, which is the form of diabetes that do not require insulin doses.

As mentioned above Cozaar is utilized for the treatment of high blood pressure. It is the first of a kind medicine from the class of drugs known as angiotensin II receptor antagonists that are generally the class of blood pressure medications. Cozaar works by preventing the process of hormone angiotensin II from blocking the blood vessels thereby reducing blood pressure. Continue reading...


Lotensin
Antihypertensive TherapyLotensin or benazepril hydrochloride is a prescription only antihypertensive drug belonging to the ACE inhibitors. It is also used for the treatment of congestive heart failure (Sweetman, 2009).
Lotensin is a nonsulfhydryl prodrug (Balfour and Goa, 1991), which means that upon administration, it is converted to its active metabolite. Specifically, the ester moiety of the drug is cleaved by the esterases found in the body, benazeprilat. This active metabolite is responsible for its antihypertensive action. The drug can be seen in the blood in as fast as one hour, reaching maximum activity within 2-4 hours. Though the maximal effect is felt in the said time, the full physiological effect may not develop for about two weeks (Sweetman, 2009). Mechanism of Action Ė The renin-angiotensin-aldosterone system (RAAS) and ACE ACE Inhibitors such as Lotensin are drugs that act on ACE involved in the renin-angiotensin-aldosterone system (RAAS). Renin, the first enzyme involved, is released from the kidneys when there is a decrease in blood pressure in the body, as signaled by low perfusion or as signaled by the sympathetic nervous system (SNS).


Metoprolol
Metoprolol works by blocking the action of the sympathetic nervous system, which is a portion of the involuntary nervous system, by blocking beta receptors on sympathetic nerves and reducing the heart rate. Metoprolol is useful in treating abnormally rapid heart rhythms because the sympathetic nervous system is responsible for increasing the heart beat rate. Also, it reduces the force of contraction of heart muscle and lowers blood pressure. By reducing this, Metoprolol also reduces the need for oxygen by heart muscle and is helpful in treating heart pain, called angina pectoris, which occurs when oxygen demand of the heart muscle exceeds the supply.


Norvasc
Why is this drug prescribed?
Norvasc is prescribed for angina, a condition characterized by episodes of crushing chest pain that usually results from a lack of oxygen in the heart muscle due to clogged arteries. Norvasc is also prescribed for high blood pressure. It is a type of medication called a calcium channel blocker. These drugs dilate blood vessels and slow the heart to reduce blood pressure and the pain of angina.

Most important fact about this drug
If you have high blood pressure, you must take Norvasc regularly for it to be effective. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Norvasc; and you must continue taking it even if you are feeling well. Norvasc does not cure high blood pressure; it merely keeps it under control. Continue reading...


 

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