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Migraine Headaches

 

Migraine is an often familial symptom of periodic attacks of vascular headache, commonly associated with irritability, nausea, vomiting, constipation and diarrhea. Attacks are preceded by constriction of the cranial arteries which activates trigeminal nerve endings in the brain. During a migraine attack, inflammation of the tissue surrounding the brain (neurogenic inflammation) worsens the pain. It characteristically affects one side of the head. Some people have an aura before an attack consisting of flickering bright lights or blurring of vision. The mechanism which causes migraine is not yet discovered, but it is known that it is an organic neurological disease, not psychological. Headache is one of its symptoms.

Products: Anti-Migraine agents

Depakote
An extended-release form of this drug, Depakote ER, is prescribed to prevent migraine headaches. The delayed-release tablets are also used for this purpose. Depakote, in both delayed-release tablet and capsule form, is used to treat certain types of seizures and convulsions. It may be prescribed alone or with other epilepsy medications. The delayed-release tablets are also used to control the manic episodes--periods of abnormally high spirits and energy--that occur in bipolar disorder (manic depression). Depakote is a prescription drug approved by the U.S. Food and Drugs Administration (US FDA) for the treatment of epileptic seizures, manic episodes of bipolar disorder (mania), and as prophylactic agent for chronic migraine. Depakote is a delayed release tablet, as opposed to its predecessor Depakene (Valproic acid) which is an immediate release tablet. Depakote is the only anti-epileptic drug approved for two non-epileptic conditions. Let us discuss each condition and relate the use of Depakote.


Seizures & Epilepsies Seizure is a disease symptom characterized by abnormal firing of neuronal impulses from the nervous system. Seizure is manifested in different forms such as altered mental state, momentary loss of senses, uncontrollable movements or even loss of consciousness. Seizure is caused by a disruption in the normal physiological state of a neuron caused by infection, stress, injury, intoxication, or an underlying disease. Continue reading...


Imigran
Imigran (sumatriptan succinate) is a drug belonging to the group of serotonin agonists. This drug is available in a variety of forms: tablets, subcutaneous injection, and nasal spray. Composed of a sulphonamide group, it is prescribed for the treatment of migraine headaches, which is caused due to widening of certain blood vessels in the brain. This drug acts by bringing back these vessels to normal and hence reducing the headache. This drug is not effective to headaches which are not migraine. One major side affect of this drug is drowsiness as reported by some users.


Topamax
migraineTopamax (topiramate) is an anticonvulsant drug for patients with epilepsy who have certain types of seizures. It is a sulfamate - substituted monosaccharide with a molecular formula of C12H21NO8S and a structural formula of

Topamax for Migraine Prevention

Antiepileptic agents such as Topamax have been shown in several studies to be efficacious in migraine prevention. Storey, et al. (2001) conducted a single-center, double-blind, placebo-controlled trial to assess the clinical safety and efficacy of Topamax in the prophylaxis of migraine. After the study period, they concluded that prophylactic therapy with Topamax significantly reduced frequency of migraine episodes among patients. Similar studies by Brandes et al. (2004) and Silberstein et al. (2007) also reported highly desirable outcomes using Topamax prophylactic therapy. Continue reading...


 

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Migraine Headaches
Migraine Headaches


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