Parkinsonism is a group of neurological disorders characterized by hypokinesia, tremor and muscular rigidity. Its most common form (Parkinsonís disease) is paralysis agitans, usually occurring in late life. There is degeneration within the nuclear masses of the extrapyramidal system and a characteristic reduction in dopamine levels. It is a slowly progressive disease characterized by mask like facies, a tremor of resting muscles, a slowing of voluntary movements, a festinating gait and peculiar posture. There may be excessive sweating and heat sensations. Although the disease cannot be cured, there are various agents which can relieve its symptoms, the most common of which are levodopa and anticholinergic drugs.
Products: Antiparkinson agents
Adamantan and Viregyt are European brand names for the antiviral drug amantadine (generic name). Amantadine is an antiviral drug which can prevent virus replication in cells. It works by preventing the virusí processes of invading and multiplying inside cells and is therefore considered as preventive rather than curative medication. To be able to render its positive effects on a person, it must be taken before the infection begins. A common warning sign that the intake of Adamantan is already too late includes fever.
Over the recent years, the secondary use of Adamantan is for Parkinsonís disease. Several clinical trials have shown that it may stop the progress or perhaps may even revert the symptoms of the disease which mainly affects the motor skills of the patient. This movement disorder is called dyskinesia. In a double-blind, randomized clinical trial, there were 36 patients of Parkinsonís disease and were divided into two groups for 300 mg of Adamantan and placebo per day in 27 days. Around 60% to 70% of the participants in the study who were affected with Parkinsonís disease to the stage of suffering dyskinesia already have shown improvement thereby demonstrating Adamantanís effectiveness. This was evaluated after 15 days with the Rush Dyskinesia Rating Scale. After the trial was stopped, the researchers then used the Unified Parkinsonís Disease Rating Scale part IV a, IV b and III.
Bromocriptine (otherwise known as Cycloset and Parlodel) is a dopamine antagonist and also an ergoline derivative which is used for treating hyperprolactinemia, Type 2 Diabetes Mellitus, pituitary tumors, neuroleptic malignant syndrome, and Parkinsonís disease. This drug may also be used for treating illnesses due to pituitary problems, such as galactorrhea, acromegaly, female infertility, hypogonadism, and amenorrhea. Side effects of taking Bromocriptine may include vomiting, nausea, orthostatic hypotension, headaches,fatigue, worsening of liver problems, dry mouth, leg cramps, vasospasm which may lead to myocardial infarction, psychomotor excitation, hallucination, confusion, pulmonary fibrosis in high dosage, and in rare cases, seizure stroke or mental disorder in post-partum women. Contraindications include uncontrolled hypertension, hypertensive disorders of pregnancy, severe cardiovascular conditions, and serious mental disorders. Continue reading...
Deprenyl, deprenyl selegiline, first intended as an antidepress≠ant, is commonly used in the treatment of Parkinsonís disease, and also as a life-extension drug. It is also being applied in the treatment of a range of other conditions. It enhances and protects mental function, and helps in retaining libido and a positive mood. Thus, particularly in its life-extension role, not just the length of life is increased, but also the quality of life. Deprenyl, which is also known by the name of Deprenyl Selegiline, is an antidepressant that is widely used in the treatment of Parkinsonís disease. The main function of Deprenyl is to assist in the protection and development of mental functions thereby assist in maintain a good mood by retaining the libido. It is said to increase the quality of life also along with the length of life, which is why it is also known as life extension drug. Deprenyl is said to be a modification of phenyl ethylamine, also known as PEA. PEA belongs to the same family to which neurotransmitters dopamine and noradrenalin belongs. Deprenyl is available in different forms like Ldeprenyl, better known as Selegiline, and deprenyl citrate. Continue reading...
Eldepryl, generic name selegiline (known in Europe under brand name Jumex) protects against aging of the brain and enhances mental function. A powerful remedy against Parkinson's disease, Eldepryl is effective also as an antidepressant and as a protector against Alzheimer's disease. Professor Knoll, who developed Selegiline is convinced of its anti-aging effect and recommends for this a dose 5 mg per week (in two doses of 2.5 mg each).
Exelon also known as rivastigmine tartrate is basically using for the treatment of mild to moderate dementia of Alzheimerís type usually associated with Parkinsonís disease. The dementia of Parkinsonís disease is characterized by effecting memory retrieval and attention in patients with diagnosis of Parkinsonís disease and it works by preventing the breakdown of the acetylcholine chemical. People suffering from dementia have lower levels of this chemical which is important for the process of memory, thinking and reasoning. The use of Exelon is associated with significant a gastrointestinal adverse reaction which includes vomiting, anorexia weight loss and nausea. For this reason it is important that the usual dose should be started with 1.5 mg of BID and titrated to their maintenance dose.
Jumex (Selegiline), also known as Deprenyl, Eldepryl works by helping to conserve the amount of dopamine available by preventing the dopamine from being destroyed. While controversial, there is some evidence that this drug may slow the progression of Parkinson's disease, particularly early in the course of the disease. Jumex works by helping to conserve the amount of dopamine available by preventing the dopamine from being destroyed. While controversial, there is some evidence that this drug may slow the progression of Parkinson's disease, particularly early in the course of the disease. This drug is well-tolerated by most people, so many experts recommend using it despite the controversies.
Indications Jumex (also known as Deprenyl, Selegiline, Emsam, Zelapar or Eldepryl) is approved for treatment of Parkinsonís disease in Europe and United States. Furthermore research findings based on animal and human experiments have shown that there is a possibility of Jumex acting as an anti-ager both in delaying the onset of age related deterioration in the functioning of the brain and in the improvement/ maintenance of sexual vigor. Jumex also has the advantage of being potent and highly selective. In fact it is the only clinically available MAO-B inhibitor. Continue reading...
Madopar is a medicine used for treating different forms of Parkinsonís diseases, except drug-induced Parkinsonism. Comprising two active ingredients called levodopa and benserazide, Madopar is categorized under group of medicines known as antiparkinsonian agents. It is available in the market under the brand name Madopar in UK and Prolopa in Canada, and both are manufactured by Roche.
Mirapexin is used to ease the symptoms of Parkinson's disease, a progressive disorder marked by muscle rigidity, weakness, shaking, tremor, and eventually difficulty with walking and talking. Mirapex is believed to work by boosting the action of whatever dopamine is available. The drug can be used with other Parkinson's medications such as Eldepryl, Sinemet, and Larodopa.
Selegiline (known as Jumex in Europe) protects against aging of the brain, enhances mental function. A powerful remedy against Parkinson's disease, Selegiline is effective also as an antidepressant and as a protector against Alzheimer's disease. Professor Knoll, who developed Selegiline is convinced of its anti-aging effect and recommends for this a dose 5 mg per week (in two doses of 2.5 mg each).
Sinemet CR is a controlled-release tablet which is used to help relieve the muscle stiffness, weakness and tremor caused by Parkinson's disease. It is also used to relieve Parkinson-like symptoms caused by brain fever (encephalitis) , carbon monoxide poisoning, or manganese poisoning.
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