Life-extension drugs

Life-extension drugs

Cancer, Breast cancer


Products: Anti-cancer drugs

breast cancerArimidex (Generic Name: Anastrozole) is a medication used for the treatment of breast cancer post-surgery and metastases in women who are post-menopausal. This drug inhibits the enzyme aromatase which works by converting androgens into estrogens in the peripheral tissues. Via competitive inhibition, the drug reversibly binds to aromatase. Through this mechanism, Anastrozole works by interrupting a crucial step in the body’s production of estrogen. Certain breast cancer cells necessitate estrogen to enable them to grow. Thus, the growth of the breast cancer cells is suppressed by eliminating estrogen. The most common side effect associated with Anastrozole is bone weakness. Women who started using it after two years of using Tamoxifen had more frequent incidence of fractures compared to those who continued taking Tamoxifen. This drug may be used with statins which can strengthen the bone to avoid fractures and cardiovascular risks. Continue reading...

Fareston (generic name toremifene) is used to slow down the growth of metastatic breast cancer which has spread from the original tumour. It works by blocking estrogen from reaching cancer cells. Some types of breast cancer require estrogen to grow. Unlike chemotherapy, fareston does not actually destroy cancer cells. Fareston is also preventing the development of prostate cancer. The recommended dosage of fareston is 60 mg once a day or as prescribed by doctor. Fareston was approved by the U.S. Food and Drug Administration for use in October 1995.

Femara (generic name letrozole) is a non-steroidal aromatase inhibitor that has been used for the adjuvant treatment of hormonally-responsive breast cancer. It works by reducing the total amount of estrogen produced primarily in the body which helps to starve cancer cells by depriving them of estrogen. The related agent to femara is anastrazole. It has also been used to treat endometriosis. Femara pcos has been use off label for ovarian stimulation by fertility doctors. The recommended dosage of femara is 2.5 mg tablet a day or as prescribed by doctor. Generally it is taken with or without food. Brand-name Femara is manufactured by Novartis Pharmaceuticals. However, the medication is also available in generic form.

Tamoxifen Nolvadex (tamoxifen) is used in the treatment of some kind of breast cancer. Nolvadex is recommended for women who are at high risk for breast cancer and for women with DCIS, but after surgery and radiation. It blocks female hormone called estrogen there by preventing the growth of tumours that are activated by estrogen. Hormones that cause breast cancer growth may also be blocked by ovarian function suppression using drugs, surgery or radiation to the ovaries. It is not yet known if giving ovarian function suppression together with tamoxifen citrate or exemestane is more effective than giving tamoxifen citrate alone in treating breast cancer.
Background of disease which the drug treat
After Lung cancer, breast cancer is classified as the most common type of cancer worldwide. According to the World Health Organization, over 1 million new cases are being diagnosed annually. In 2000, almost 400,000 women died from it, representing about 1.6% of all female deaths, and in 2008, about 480,000 women. It is the fifth leading cause of cancer death. Continue reading...

Tamoxifen (Zitazonium)
breast cancerTamoxifen, discovered by ICI Pharmaceuticals and sold under the trade names Nolvadex, Zitazonium, is an anti-oestrogen drug which is widely use to treat breast cancer that has spread to other parts of the body in men and women, to treat early breast cancer in women who have already been treated with surgery, radiation or chemotherapy. Is is also known to reduce the risk of developing a more serious type of breast cancer in women who had ductal carcinoma and who have been treated with surgery and radiation and also reduces the risk of breast cancer in women who are at high risk for the disease due their age, personal medical history or family medical history. Tamoxifen is sold as tablets, which come in different strengths: 10mg, 20mg or 30mg and can be taken with or without food. Most common side effects are hot flushes and sweats, nausea and indigestion, change in periods, weight gain or leg cramps, depression or voice changes. Tamoxifen can interact with other medicines so let your doctor know about any drugs you are taking, including non-prescribed drugs. Other Names of Tamoxifen: Nolvadex, Dignatomoxi, Emblon, Fentamox, Istubol, Kessar, Mamofen, Noltam, Novofen, Oestrifen, Tamaxin, Tamifen, Tamoplex, Tamoxen, Valodex, Zitazonium.


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Cancer, Breast cancer
Cancer, Breast cancer

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