E vitamin prescribing information
Results of scientific studies indicated that standard diet (2000cal, vitamin E intake is 8-10 IU) does not provide us the recommended daily intake for vitamin E (10-30 IU) and anti-aging daily intake (200-400 IU). Our bodies can not produce vitamin E and we need taking of vitamin E in supplements form.
It has been claimed that ?-tocopherol is the most important lipid-soluble antioxidant, and that it protects cell membranes from oxidation by reacting with lipid radicals produced in the lipid peroxidation chain reaction. This would remove the free radical intermediates and prevent the oxidation reaction from continuing. The oxidised ?-tocopheroxyl radicals produced in this process may be recycled back to the active reduced form through reduction by other antioxidants, such as ascorbate, retinol or ubiquinol. However, the importance of the antioxidant properties of this molecule at the concentrations present in the body are not clear and it is possible that the reason why vitamin E is required in the diet is unrelated to its ability to act as an antioxidant.. Other forms of vitamin E have their own unique properties. For example, ?-tocopherol (also written as gamma-tocopherol) is a nucleophile that can react with electrophilic mutagens.
However, the roles and importance of all of the various forms of vitamin E are presently unclear, and it has even been suggested that the most important function of vitamin E is as a signaling molecule, and that it has no significant role in antioxidant metabolism.
So far, most studies about vitamin E have supplemented using only the synthetic alpha-tocopherol, but doing so leads to reduced serum gamma- and delta-tocopherol concentrations. Moreover, a 2007 clinical study involving synthetic alpha-tocopherol concluded that supplementation did not reduce the risk of major cardiovascular events in middle aged and older men. For more info, read article tocopherol.
Mol Nutr Food Res. 2010 May;54(5):719-25.
Vitamin E supplementation and mammalian lifespan.
Banks R, Speakman JR, Selman C.
Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK.
Vitamin E refers to a family of several compounds that possess a similar chemical structure comprising a chromanol ring with a 16-carbon side chain. The degree of saturation of the side chain, and positions and nature of methyl groups designate the compounds as tocopherols or tocotrienols. Vitamin E compounds have antioxidant properties due to a hydroxyl group on the chromanol ring. Recently, it has been suggested that vitamin E may also regulate signal transduction and gene expression. We previously reported that lifelong dietary vitamin E (alpha-tocopherol) supplementation significantly increased median lifespan in C57BL/6 mice by 15%. This lifespan extension appeared to be independent of any antioxidant effect. Employing a transcriptional approach, we suggest that this increase in lifespan may reflect an anti-cancer effect via induction of the P21 signalling pathway, since cancer is the major cause of death in small rodents. We suggest that the role of this pathway in life span extension following supplementation of vitamin E now requires further investigation.
Notes on Vitamin E (E Vitamin):
Available with the product name Alpha E, E vitamin is an antioxidant that cannot be synthesized by our body and thus needs to be added to the body in the form of drug or supplements. E vitamins are prescribed to protect the cells of our body against the ill effects of free radicals that can lead to the potential damage of the energy metabolism of our body. This vitamin is also highly essential in strengthening the immune function of the body along with the DNA repair and several other metabolic functions. Owing to these properties, E vitamins are incorporated in several anti-aging supplements.
Before prescribing for the drug, your doctor may inquire if you have any of the conditions including bleeding, anemia, recent surgery or stroke, allergic reaction to vitamin E, pregnant or breast feeding. This medicine is taken orally and for better results it is advised to take it with food, that too at regular intervals. Taking vitamin dosages more than that is directed by your doctor can be harmful for the body. You require consulting doctor before giving E vitamin to children. If any case of over dosage is identified, it is required to contact the nearest poison control center or emergency room immediately.
Your health care provider will also inquire you about other drugs, herbs or supplements that you have been taking so far before prescribing E vitamin, as there are some possible drug interactions that may occur when using E vitamins. People using drugs like cholestyramine, orlistat, mineral oil, warfarin etc should avoid this medicine. It is strictly advised that you should make essential consultation with your health provider about the lists of drug that are being used other than the above as it can increase the effect of vitamin E. Using alcohol is also prohibited.
Some common side effects of the drug include: allergic reactions like skin rash, itching hives etc, swelling of the face, lips, or tongue, diarrhea changes in vision nausea, vomiting, dizziness, headache, unusual weakness, stomach pains, unusual bleeding etc
Mol Aspects Med. 2007 Feb 23;
Neuzil J, Dong LF, Ramanathapuram L, Hahn T, Chladova M, Wang XF, Zobalova R, Prochazka L, Gold M, Freeman R, Turanek J, Akporiaye ET, Dyason JC, Ralph SJ.
Apoptosis Research Group, School of Medical Science, Griffith University, Southport, Qld, Australia; Molecular Therapy Group, Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic.
Vitamin E analogues as a novel group of mitocans: Anti-cancer agents that act by targeting mitochondria.
J Trace Elem Med Biol. 2007;21(2):113-9.
Faure P, Barclay D, Joyeux-Faure M, Halimi S.
Laboratoire HP2, Hypoxie Physio-Pathologie Respiratoire et Cardiovasculaire, Inserm ERI 0017, Faculte de Medecine-Pharmacie, BP 217, 38043 Grenoble cedex 9, France.
Comparison of the effects of zinc alone and zinc associated with selenium and vitamin E on insulin sensitivity and oxidative stress in high-fructose-fed rats.
Fertil Steril. 2007 May 4;
Aybek H, Aybek Z, Rota S, Sen N, Akbulut M.
Department of Biochemistry.
The effects of diabetes mellitus, age, and vitamin E on testicular oxidative stress.
Clin Exp Hypertens. 2007 Mar-Apr;29(3):135-48.
Heart and Kidney Institute, University of Houston, College of Pharmacy. Houston, Texas. USA.
The use of vitamin e in type 2 diabetes mellitus.
Surgery. 2006 Oct;140(4):607-15.
Peralta EA, Viegas ML, Louis S, Engle DL, Dunnington GL.
Department of Surgery, Southern Illinois University School of Medicine, Springfield, Ill.
Effect of vitamin E on tamoxifen-treated breast cancer cells.
E vitamin review article...
Antioxidants and Vitamines
E vitamin prescribing information