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Mirapexin Review Article

 

Mirapexin is used to ease the symptoms of Parkinson's disease, a progressive disorder marked by muscle rigidity, weakness, shaking, tremor, and eventually difficulty with walking and talking. Mirapex is believed to work by boosting the action of whatever dopamine is available. The drug can be used with other Parkinson's medications such as Eldepryl, Sinemet, and Larodopa.

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Why is this drug prescribed?
Although it is not a cure, Mirapex eases the symptoms of Parkinson's disease--a progressive disorder marked by muscle rigidity, weakness, shaking, tremor, and eventually difficulty with walking and talking. Parkinson's disease results from a shortage of the chemical messenger dopamine in certain areas of the brain. Mirapex is believed to work by boosting the action of whatever dopamine is available. The drug can be used with other Parkinson's medications such as Eldepryl, Sinemet, and Larodopa.

Most important fact about this drug:
If you are taking Sinemet or Larodopa, Mirapex may allow a reduction in your dosage. And if you suffer from the "on-off" effect that often develops during Parkinson's therapy (symptom-free periods alternating with severe attacks), Mirapex may extend the good "on" times and shorten your "off" periods.

How should you take this medication?
Take Mirapex exactly as prescribed. If it makes you nauseous, try taking it with food. When discontinuing Mirapex therapy, it's best to do it gradually. Your doctor will tell you how to taper your dose over a week's time.
• If you miss a dose...
Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at the same time.
• Storage instructions...
Store at room temperature; protect from light.

What side effects may occur?
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Mirapex.
• More common side effects may include:
Abnormal dreams, arthritis, chest pain, confusion, constipation, decreased sensitivity to touch, difficulty breathing, difficulty walking, dizziness, dizziness upon standing, drowsiness, dry mouth, hallucinations, increased muscle tone, increased urination, insomnia, involuntary movement (jerky motions), lack of appetite, memory loss, nasal inflammation, nausea, swelling, urinary tract infections, vision abnormalities, weakness
• Less common side effects may include:
Decreased sex drive, delusions, difficulty swallowing, fever, general feeling of illness, impotence, inability to hold urine, muscle spasms or twitching, pneumonia, skin disorders, thinking abnormalities, uncontrollable restlessness, unfounded suspicions, weight loss
• Rare side effects may include:
Abnormal ejaculation, abnormal heartbeat, agitation, blood clots, blood in urine, blood circulation problems, convulsions, difficult or painful urination, enlarged abdomen, eye disorders, heart attack, heart problems, joint problems, lung problems, mental illness, muscular problems, prostate problems, severe chest pain (angina), thirst

Why should this drug not be prescribed?
If Mirapex gives you an allergic reaction, you'll be unable to use it.

Special warnings about this medication:
Mirapex can cause your blood pressure to drop when you first stand up, resulting in symptoms such as dizziness, nausea, fainting, blackouts, and, sometimes, sweating. To avoid or reduce these symptoms, try to stand up slowly, especially at the beginning of treatment with Mirapex.
Mirapex can cause drowsiness and may trigger hallucinations, especially if you are over 65 or have an advanced case of Parkinson's. You may even fall asleep--without warning and without feeling drowsy--while performing everyday activities. Check with your doctor immediately if you find that you're getting drowsy or falling asleep while eating, talking, or watching television. Do not drive a car or undertake other dangerous activities until you've spoken with the doctor. Be especially cautious when taking other drugs that cause sleepiness.
If you have a kidney condition, make sure the doctor is aware of it. You'll probably need regular blood tests to check your kidney function, and your dosage of Mirapex may have to be reduced.
In very rare cases, Mirapex may cause muscle wasting. If you develop muscle aches or soreness after you start Mirapex, be sure to tell your doctor. Also alert your doctor if you notice any changes in your eyesight.

Possible food and drug interactions when taking this medication:
If Mirapex is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Mirapex with the following:
Carbidopa/Levodopa (Sinemet)
Sedatives and tranquilizers such as chloral hydrate, codeine products, Dalmane, Halcion, and phenobarbital
Cimetidine (Tagamet)
Diltiazem (Cardizem, Dilacor XR)
Major tranquilizers such as Compazine, Haldol, Mellaril, Navane, Prolixin, Stelazine, and Thorazine
Metoclopramide (Reglan)
Quinidine (Quinidex, Quinaglute)
Quinine
Ranitidine (Zantac)
Triamterene (Dyrenium)
Verapamil (Calan, Isoptin)

Combining Mirapex with Sinemet or Larodopa sometimes triggers twitching and jerky movements. If this happens, tell your doctor. A reduction in your dose of Sinemet or Larodopa may solve the problem.

Special information if you are pregnant or breastfeeding:
The effects of Mirapex during pregnancy have not been adequately studied, so it's best to avoid it if you're expecting. If you are pregnant or plan to become pregnant, inform your doctor immediately.
It is not known whether Mirapex appears in breast milk. If the drug is considered essential to your health, your doctor may advise you to stop breastfeeding while taking the medication.

Recommended dosage:
ADULTS:
The usual starting dose is 0.125 milligrams 3 times a day. If necessary, your doctor may increase the dose every 5 to 7 days until the maximum dose of 4.5 milligrams a day is reached. Dosage is usually increased gradually to minimize the drug's potential side effects. If you have kidney disease, the doctor will keep the dosage quite low.
CHILDREN:
The safety and effectiveness of this drug in children have not been established.

Overdosage:
Although there is no information on Mirapex overdose, any medication taken in excess can have dangerous consequences. If you suspect an overdose, seek medical attention immediately.

Caution! Before starting to take this medicine, it is vital that you should consult your doctor! Do not use it on your own initiative, without medical advice.


Mirapexin notes:

Mirapexin, which has the Generic name as Pramipexole dihydrochloride is used widely to treat the symptoms of Parkinson’s disease. Though it’s not a complete cure for this disease, but it helps in easing the symptoms of it. Parkinson’s disease gives troubles like difficulty in walking, muscle rigidness, weakness, tremor, shaking and in talking too. This is caused due to shortage of dopamine in brain. Hence the Mirapexin triggers the activities of the present dopamine. Doctors prescribe this medicine for treatment of Larodopa, Sinemet and Eldepryl in Parkinson’s disease.

More common side effects are like dizziness, headache, dry mouth, hallucination, memory loss, appetite loss and some more, while less common are restlessness, suspicions, pneumonia, impotence etc. Some very rarely found problems are eye disorders, blood clotting problem, angina, painful urination etc. This miapex can be known as pramipexole or prmipexole dihydrochloride also.
Its more effective if given to the patients in an early stage of disease but less if given at advanced stage. Mirapex effects are known around the world that is why this medicine is considered as the best medicine to treat Parkinson’s disease in manycases.

Mirapexin side effects are rare or mild. In case of individual there might be urticaria, allergic hypersensitiveness reaction, or shock state of mind every time. If some side effects you observe are not in the abovementioned list then contact your doctor immediately. Mirapexin medication is taken only after doctor’s advice.

Medication mirapexin are given to patient suffering from Parkinson’s disease. After 4 weeks of therapeutic measures the doctor will decide for the further therapeutic measure is required or not. Make sure that the medicines should be taken on the advised of the physician and timings are also an issue that has to be taken care of. You should go to the physician immediately in case of any irritation.


 

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