Bexarotene quickly Reverses Alzheimer's Symptoms in Mice
Alzheimer's disease is one of the common diseases to be found in the Americans. This disease is actually the most common form of the dementia that gradually get worsen and eventually leads to death. Neuroscientists worked a lot to find the cure of this disease and at last the neuroscientists of the Case Western Reserve University School of Medicine became succeeded in finding the cure of this disease. These neuroscientists found that the use of the drug bexarotene in mice relieves the symptoms of Alzheimer's disease. The U.S. Food and Drug Administration approved the bexarotene for more than a decade.
Alzheimer's disease actually arises when our body becomes unable to eliminate the amyloid beta from the brain. So the amyloid beta deposits are the fundamental cause of the Alzheimer's disease. In 2008 Gary Landreth (the professor of neurosciences in the Case Western Reserve University School of Medicine) discovered that the Apolipoprotein E (ApoE), the main cholesterol carrier in the brain, facilitated the clearance of the amyloid beta proteins. Landreth and his colleagues in their study found that the bexarotene increases the Apolipoprotein E level in the brain. The increase in the level of the Apolipoprotein E in the brain ultimately increases the clearance of amyloid beta proteins from the brain. Bexarotene actually stimulates the retinoid X receptors which stimulates the Apolipoprotein E production.
Alzheimer’s disease is also linked with the genetic factor. Humans have three forms of Apolipoprotein E which are ApoE2, ApoE3 and ApoE4. Researchers found that the possession of ApoE4 gene greatly increases the risk of Alzheimer’s disease. Actually this form of ApoE is unable to clear amyloid beta while all other forms of ApoE increase the clearance of amyloid beta.
All the scientific researchers are surprised to see the effect of bexarotene on the Alzheimer's disease. During their research they found that the bexarotene decreases the amyloid beta level (particularly soluble form which is supposed to cause the memory impairments in animal models) by 25 percent within 6 hours of its administration. The effect of the bexarotene also remains for about three days. All this was studied on the three different mouse models of Alzheimer’s disease.
Researchers also found that the bexarotene not only decreases the soluble form of amyloid beta but also decreases the deposited form of amyloid beta within the brain. They found that both the soluble and the deposited forms of amyloid beta are the cause Alzheimer’s disease. They observed that the bexarotene removed more than half of the deposited amyloid beta within 72 hours of administration.
Mice possess the typical nesting behavior in themselves. During the research on mice it was observed that when the mice are suffering from the Alzheimer’s disease then they are unable to maintain their inherent habit of nesting. It was observed that when the Alzheimer’s- diseased mice found some material suited for nesting like tissue paper they did nothing for the creation of space to nest. This showed that the mice had lost their inherent ability to nest due to Alzheimer’s disease. In the same research it was also observed that when the bexarotene is administered to the Alzheimer’s- diseased mice then they started to use the tissue paper to make nests just after 72 hours of administration.
It was also observed by the researchers that the bexarotene works well in the Alzheimer’s- diseased mice but it has to be ascertain that either it works well in the humans or not. It was also observed that the bexarotene possess a good safety and side-effect profile so the clinical trials of this drug can be easily conducted.