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A study on the origin of Alzheimer brain plaques

A study on the origin of Alzheimer brain plaques

A recent study was conducted by the U.S researchers on the origin of Alzheimer brain plaques. The research helps them to find the normal intake and communication processes of a nerve cell which is necessary for the development of Alzheimer's brain plaques.

Based on the research the Washington University School of Medicine researchers in St. Louis reported that the Alzheimer brain plaques are the accumulations of fragments of amyloid beta protein. These plaques are found in the brains of Alzheimer’s patients and are revealed on post-mortem examinations.

During the research, the researchers controlled the endycytosis - the capability of brain cells to acquire in substances from the surface. They injected a drug in mice with a disease similar to Alzheimer's to stop the process of endocytosis. After the injection of the drug, it was found that the production of amyloid beta protein has been reduced by 70 percent.

The researchers injected another drug in mice which can reduce the brain cell communication. This time endocytosis was not affected and the result was 60 percent reduction in the production of amyloid beta protein.

According to John Cirrito - a research instructor and first author of the study, it is not a viable method to block the endocytosis because the cells in the body including the brain cells need the process to function normally. The researchers start trying to find the origins of amyloid beta protein in more detail soon. This research report was published in the journal Neuron.

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