The Scientists in Japan claim that they have succeeded in discovering the possibility to delay or prevent heart failures in humans.
In a leading journal Circulation, the renowned researcher and assistant professor of medicine at Kyoto University Graduate School of Medicine in Kyoto, Mr. Tetsuo Shioi, and his team published a paper that describes the strain that was involved in suppressing P13K gene variety in a group of old mice. The genes that they suppressed mainly control the lifespan of cells and the aging of tissues.
As per the previous studies that they conducted on roundworm, it was found that the inhibition of these gene groups helped in extending the lifespan of the roundworm and made the hearts of old fruit flies strong and healthy.
According to another research on a new group of mice where these genes were left intact it was found that the suppressed genes helped in enhancing their cardiac function along with less fibrosis that makes the heart inflexible and offered less biological aging marks.
Shioi further added that their studies have been successful in revealing that by modifying the function of insulin aging of the heart can be prevented and age-associated susceptibility to heart failures can also be prevented.
As per the reports of World Health Organization, old age is the major risk factor for heart failure. With aging, the capability of the heart to pump enough blood around the body parts is reduced and this reduces the capability of the heart to supply sufficient oxygen to other parts.
American Heart Association reports that 5.7 million Americans suffer from heart failure, and just about 10 out of every 1,000 people more than 65 years suffer from heart failure each year.
According to Mariell Jessup, the professor of medicine at the University Of Pennsylvania School Of Medicine in Philadelphia, elderly people are prone to slow loss of heart cells and therefore suffer from other cellular abnormalities that make the remaining cells also less efficient.
The early work of Tetsuo Shioi in a mouse model offers strong clarification regarding the role of PI3K in cardiac aging. He said that this could eventually permit scientists to understand if human hearts are influenced similarly.
Mice are also the best surrogate for studies of human diseases and conditions like mammals to study their body plan, physiology and their genome share many features with humans.