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Proscar Review Article

 

Proscar (Generic name: Finasteride) is an oral drug that is used to help shrink enlarged prostate. Prostate enlargement, also known as Benign Prostate Hyperplasia (BPH), is non-cancerous but often results to the obstruction of the urine flow from the bladder. Aside from shrinking enlarged prostate, Proscar is also used to treat hair loss problems among males. In fact, Proscar has been approved by the FDA for hair loss treatment. The side effects of taking Proscar include decrease of semen per ejaculation, impotence or decreased in sex drive. On the other hand, no significant drug interactions are reported with this particular drug.

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Proscar (Generic name: Finasteride) is an oral drug that is used to help shrink enlarged prostate.One of the most common diseases that affect the male population is complications of the prostate gland such as prostate cancer. It is usually hard to detect in the first few stages as it is asymptomatic. When a person with prostate cancer does notice it, though as sexual intercourse difficulties, painful urination or erectile dysfunction arises, the disease may be too late to treat. Often times, the cancer cells would have already metastasized aggressively to proximate parts of the male reproductive gland such as bones or lymph tissues.


As health experts are trying to research on new ways to effectively diagnose prostate cancer earlier on, another set of research is being conducted on the effectiveness of Proscar. This is a trademark drug for the generic Finasteride which intervenes by slowing down or halting the conversion of androgen testosterone to 5α-dihydrotestosterone through the primary artificial compound content of 4-azasteroid. As this is a brand name, there are other forms of Finasteride other than Proscar but it is one of the drugs which come as highly prescribed by physicians. Manufactured by pharmaceutical company Merck, Proscar is most taken in as tablets.


Though Proscar's main purpose is for treating benign prostatic hyperplasia as well as male pattern baldness which was authorized by the United States FDA, many studies have been further conducted with regards to its effects for prostate cancer as it has shown promise prior to testing on clinical trials. Earlier on its introduction to the pharmaceutical market, those male individuals who have been prescribed and using Proscar have displayed beneficial results for improvement of symptoms which vary from reduction of urinary pain and discomfort to decrease of risk for surgical and other invasive measures that doctors best prefer avoided.


The clinical trials for Proscar would start off with taking a biopsy of the tissue of the reproductive gland. This is done to be able to confirm which of the participants in the group are affected with the condition. However, one group of researchers has also used this as the focal point of their study due to the fact that most individuals have negative prostate biopsy. Their main objective is to heck if Proscar will be able to give an enhancement in this stage for better results accuracy. As they found out, using this particular Finasteride drug was able to aid in increasing the success rate for detecting prostate cancer in earlier stages. The required time for taking in Proscar is more or less six months to be able to yield the effects needed. After this time frame of continuous exposure to at least 5 mg of the drug each day, biopsies were taken again and had finally confirmed with a positive result.


proscar, buy proscar, buy clomideThe physicians who are conducting the study in New York among more than 100 males above the age of 18 years old have a lead on the cause of this result. This study continued for a full year. PSA or prostate-specific antigen was most likely the reason behind the improvement of accuracy of biopsy tests. The interaction between Finasteride with the PSA has caused a great reduction in the former thereby allowing a positive result due to the heightened levels of a factor where diagnosis is dependent on. This first conclusion from such a clinical trial that investigates the effectiveness of Proscar for a stage that is the most difficult and unexplored for a widespread disease has elicited further research from the year 2010 up until today regarding it to carry on to be able to establish the connection between positive detection and the mechanism of action of the drug.


Moving forward, Proscar is primarily targeted towards the treatment of benign prostatic hyperplasia which has the main symptom of prostate gland enlargement. This is another male reproductive disease that commonly occurs amounting to cases of 50% in males over the age of 50 and 75% over the age of 80. Though the growth is not malignant and will not metastasize such as that of cancer, the problem is the obstruction with the urinary tract of the males causing difficulty in elimination and thereby further complications with the kidneys.


As a focused study on Proscar, the manufacturing company Merck has conducted its safety and efficacy in terms of use for benign prostatic hyperplasia. The study lasted for 48 weeks and involved male participants from the age of 50 to 79 years of age who were positively diagnosed with the condition but not with prostatic cancer. The results from the study determined that Proscar has scored high on both aspects of the course as based on improvement with International Prostate Symptom Score, QOL-index, percentage of maximum urinary flow rate and prostate volume after daily intake as compared to the group which was put on placebo treatment.


One of the most recent studies with Proscar and other Finasteride drugs was conducted by Eli Lilly and company with an interventional and efficacy endpoint approach. In this matter, the researchers used a study group of more than 100 with all males not less than 45 years of age. The study lasted for a total of 26 weeks. The main focus is the drug interaction between Finasteride in general and Tadalafil. The latter is an inhibitor type of drug that is used in treating erectile dysfunction as well as arterial hypertension. It works by boosting quantities of cGMP which are produced as an important part for increasing blood flow to the smooth muscles, surrounding vessels and tissues of the penis. The study started with a few routine tests of the individuals. No healthy male were to take part in this trial and all either had prostate enlargement or lower urinary tract obstruction due to benign prostatic hyperplasia. Levels of PSA and other androgenic hormone related substance in the blood were obtained as baseline data.


To be able to be included in the study, the individuals had to pass through rigorous screening with established inclusion criteria such as BPH, overactive and erectile dysfunction therapy for a minimum of 4 weeks as well as exclusion criteria of vital organ conditions. As the participants in the study took one dosage of tadalafil along with finasteride each day for the whole period of 6 months, the end results have proven that such an option for treatment was viable for the lessening of symptoms of enlargement as the success rate was seen after 26 weeks in terms of IIEF (International Index of Erectile Function) as well as PVR (Post Void Residual) volume as compared to the initial data prior to the continuous intake of both drugs. Though there is no specific percentage published, the conclusion is that such a method of combining Proscar with any Tadalafil drug will treat safely and effectively.


Proscar is prescribed to help shrink an enlarged prostate.Another interesting discovery that extends the benefits of using Proscar is its curative effect in a condition called idiopathic hirsutism. As it is already known, Finsateride has been prescribed to men who have male pattern baldness but in this instance, the females are given such a drug to prevent any excessive facial and body hair growth. In this case, a topical form of administrating Proscar was employed. The overall study lasted for a period of 6 months and involved the use of 0.2% Finasteride cream two times a day each day. The study group was composed of all females who had idiopathic hirsutism. Though little is known about the cause of condition, there is a common understanding that it arises from hormone imbalance especially that of androgens which are responsible for hair growth. This characteristic could explain the successful results afterwards as Finasteride drugs are known to interfere with testosterone transformation in the body.


More studies are on their way for further bolstering of the theory but the data taken from the period of study shows that Proscar will definitely show promise with treating idiopathic hirsutism based on comparative analysis from beginning to end Ferriman-Gallwey score which is used to examine 9 to 11 body parts prone to excessive hair growth and mere observation of apparent decrease of thickness of hair distribution. Additional factors that were used to determine a more refined outcome from the study are the levels of androgens as well as period of ovulation and serum prolactin in the involved females of the group.


The years go by and experts have been finding newer treatments to extend the coverage of benefits that can be reaped from Proscar. One of the youngest studies that have shown results which were previously known is the relation of Finasteride to hematuria and hematospermia. These conditions are closely related to prostatic or male reproductive function. Hematuria is defined as the appearance of blood with the urine whereas hematospermia as the appearance of blood in the seminal fluid. Similar to the previous conditions, little knowledge has been gathered for now regarding these conditions but is being pointed to a prostate infection. According to the study by Health Canada and Merck, the intake of 5 mg of finasteride once each day for a total of 14 days before transrectal ultrasound and proceed with the regimen after a total of 7 days prevented both of the conditions to result.



REFERENCES:



1. Kaplan, S.A,. Ghafar, M.A., Volpe, M.A., Lam, J.S, Fromer, D. and Te, A.E. 2002. PSA response to finasteride challenge in men with a serum PSA greater than 4 ng/ml and previous negative prostate biopsy: preliminary study. Urology 60(3):464-8.

2. Lilly, E. 2011. A Phase 3b, Randomized, Double-blind, Placebo-controlled Parallel-design Study to Evaluate the Efficacy and Safety of Tadalafil Co-administered With Finasteride for 6 Months in Men With Lower Urinary Tract Symptoms and Prostatic Enlargement Secondary to Benign Prostatic Hyperplasia.

3. Merck. 2005. MK0906 Phase III Double-Blind Comparative Study - Benign Prostate Hyperplasia

4. Heydari, I. The Efficacy of Topical Finasteride in the Treatment of Idiopathic Hirsutism.

5. Pommerville M.D., P. 2010. The Use of Finasteride to Reduce Hematuria and Hematospermia Following TRUS Prostate Biopsy.


 

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