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Raloxifene Review Article

 

Raloxifene (generic name: raloxifene) is an oral drug that prevents osteoporosis. Osteoporosis is a disease that is characterized by having fragile bones. It is common among women who have undergone menopause. Raloxifene reduces the incidence of vertebral structure by acting as the agonists of the oestrogen receptor in different tissues of the body, which initiates the formation of fragile bones. Raloxifene is also taken alongside with Vitamin D and Calcium, which makes the action of the drug more efficient. The side effects that have been recorded when taking Raloxifene include vasodilation and flu-like symptoms. Moreover, patients who are pregnant, have blood clot disorders and other cardiovascular anomalies are discouraged to take the medicine.

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Raloxifene generic (generic - what is it?)

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What is Evista?
Evista is a medicine containing the active substance raloxifene hydrochloride. It is available as white, oval tablets (60 mg).

What is Evista used for?
Evista is used for the treatment and prevention of osteoporosis (a disease that makes bones fragile) in women who have been through the menopause. Evista has been shown to significantly reduce vertebral fractures (breaks in the spine), but not hip fractures.

How is Evista used?
The recommended dose for adults and the elderly is one tablet taken once a day, with or without food. Patients may also receive calcium and vitamin D supplements if they do not get enough from their diet. Evista is intended for long-term use.

How does Evista work?
Osteoporosis happens when not enough new bone grows to replace the bone that is naturally broken down. Gradually, the bones become thin and fragile, and more likely to break (fracture). Osteoporosis is more common in women after the menopause, when the levels of the female hormone oestrogen fall: oestrogen slows down bone breakdown and makes the bones less likely to fracture. The active substance in Evista, raloxifene, is a selective oestrogen receptor modulator (SERM). Raloxifene acts as an Ďagonistí of the oestrogen receptor (a substance that stimulates the receptor for oestrogen) in some tissues in the body. Raloxifene has the same effect as oestrogen in the bone, but it does not have an effect in the breast or the womb.

How has Evista been studied?
Evista has been studied in the treatment and the prevention of osteoporosis in four main studies. Three studies looked at the prevention of osteoporosis in 1,764 women who took either Evista or placebo (a dummy treatment) for two years. The studies measured the density of the bones. The fourth study compared the effects of Evista with those of placebo in the treatment of osteoporosis in 7,705 women over four years. The main measure of effectiveness was how many women had vertebral fractures during the study.

What benefit has Evista shown during the studies?
Evista was more effective than placebo in preventing and treating osteoporosis. In the prevention of osteoporosis, women receiving Evista had an increase in bone density in the hip or spine of 1.6% over two years, and those receiving placebo had a decrease of 0.8%.
When used to treat osteoporosis, Evista was more effective than placebo in reducing the number of vertebral fractures. Over four years, in comparison with placebo, Evista decreased the number of new vertebral fractures by 46% in women who had osteoporosis and by 32% in women who had osteoporosis and an existing fracture. There was no effect of Evista on hip fractures.

What is the risk associated with Evista?
The most common side effects with Evista (seen in more than 1 patient in 10) are vasodilation (hot flushes) and flu-like symptoms. For the full list of side effects reported with Evista, see the Package Leaflet. Evista should not be used in women who:
could become pregnant; have or have had any blood clot disorders, including deep vein thrombosis and pulmonary embolism (a blood clot in the lungs); have liver disease, severe kidney disease, unexplained bleeding from the womb or endometrial cancer (cancer of the lining of the womb). Evista should not be used in people who may be hypersensitive (allergic) to raloxifene or any of the other ingredients.


 

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