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Red Wine high in Resveratrol Review Article

 

Hungarian red wine Pinot Noir has one of the highest content of Resveratrol, Quercetin and Anthocianins. The highest polyphenol content and antioxidant activity was in Pinot Noir and in Merlot from Villany.
See also: General premature aging.


Most of us wish at one time or another for that magic bullet: a simple pill that would safely and effectively reduce the effects of aging; prevent cancer, heart disease, and diabetes; increase memory, and extend life, and all without having to count calories.

The magic bullet may have been found when David Sinclair at Harvard University and his colleagues demonstrated that resveratrol, a chemical found in plants, mimics the effects of CR. Just as limiting calories triggers the low-level stress response - hormesis - which, in turn, jump-starts the SIRT1 longevity gene, resveratrol mimics this stress, activating SIRT1.

For years many CR researchers have stated that they hope calorie restriction science will lead to the development of calorie restriction mimetics, that is, drugs that mimic the health and longevity benefits of a calorie restriction without the need to limit calories. Now resveratrol has emerged as the leading candidate for the mimetic many hoped for. The key to resveratrol benefits is that it activates the same longevity genes and cell-signaling pattern as calorie restriction.

What has excited the scientific community is the research showed that resveratrol may not only provide the same beneficial as CR without restricted calories, but it may also, in fact, counteract the damage effect of high-caloric diet. In the latest study by Dr. Siclair's lab and the National Institute of Aging, a group of mice was fed a diet consisting of 60 percent fat, which, unsurprisingly, caused weight gain, symptoms of diabetes, and early death. Another group of mice was fed the same diet but was given resveratrol. Although they gained as much weight as the controll group, these mice showed no signes of the elevated glucose and insulin levels that would indicate diabetes.

Some red wines like Hungarian Pinot Noit may contain high amount of resveratrol, as do grapes, rasberries, peanuts, and numerous other plants.

Red wine is a rich source of resveratrol, and contains significantly more resveratrol than white wine. This is because the grape skins are left in with the juice for longer when making red wine, and the skins are where most of the resveratrol is found. The resveratrol content varies considerably from one red wine to another, however. So, what are the best red wines for resveratrol content?

By far the highest resveratrol content (around 40mg/L) is found in both red and white wines made from the thick-skinned Muscadine grape.

Other red wines typically contain between 2 and 12.5mg of resveratrol per liter. Of the more popular grape varieties, Pinot Noir produces wines with the highest average resveratrol levels. The Pinot Noir grape tends to thrive in temperate, damp climates which also encourage molds and yeasts that attack vines and other plants. In this humid environment, plants produce increased quantities of resveratrol to defend against oxidization damage from fungal growth and other external pressures. Scientists have discovered that resveratrol has similar antioxidant benefits for the human body.

Pinot Noir from its native Burgundy, France, as well as from Hungary generally contains more resveratrol than the equivalent wine from a hotter, dryer area such as California or Australia. Levels will also vary significantly from one vintage to another depending on the temperature and rainfall during the growing period. Pinot Noir red wine from Hungary often contains 30 mg/L and higher of Resveratrol.

See also: Flavonoids


Scientists reluctant on red wine as anti aging drug A report:

According to the latest developments, scientists have raised a voice of doubt over anti aging drugs that can cheat the biology of aging. Researchers from the drug companies like Amgen in Thousand Oaks, California and Pfizer have questioned the claims made on compounds that include much praised component of red wine, resveratrol which is believed to help in delaying old age.

In a report published in Journal of Biological Chemistry, Pfizer team had said that resveratrol and other claimed compounds does not work as expected during the series of new studies that were being conducted. The team from Amgen had also revealed that resveratrol does not activate SIRT1 which is a protein implicated in aging.
Matt Kaeberlein from the University of Washington, Seattle who was not involved in any of the developments has showed a deep concern as this claims from researchers can prove to be a major setback in further developments of anti aging drugs using compounds like resveratrol.


 

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