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Rhodiola root prescribing information

 



Rhodiola rosea benefits

Rhodiola(Rodiola) root scientific name Rhodiola rosea is used to prevent fatigue and to enhance physical and mental performance. Rhodiola contains active substance Rosavin and is considered an adaptogen which is an agent that works in the cells to normalize function and stimulate healing. Rhodiola may provide benefits in bladder cancer, lung disease, exercise and mental performance. Rhodiola rosea extract is mainly used in the form of capsules or a tablet although tinctures are also available. A significant effect for Rhodiola extract has been observed in doses of 340-680 mg per day in patients with mild to moderate depression.




Rhodiola Rosea

As the popularity of natural medications, remedies and tinctures continue to return as an alternative to the chemically produced drugs and medicines, people have become acutely aware of the benefits of making such a switch. Needless to say despite the fact that a product may well be deemed to be natural, there are still some contra-indications, side effects and related information that requires specific attention prior to undertaking a course of any natural remedy or alternative for any given condition, illness or disease.

This naturally based medication has been used for over 2,000 years within the treatment of a variety of conditions. Rhodiola Rosea is also referred to as Siberia’s Golden Root as it is indigenous to the arctic regions of Europe, Eurasia and Siberian Asia; although the leaves are used within a variety of applications, the predominant part of this plant that is utilized is the root, which as expected is a yellow gold colour. The consumption of the root itself, within its dried form was heralded as a closely guarded secret for longevity, as well as mental and physical performance improvement by the then Soviet athletes and cosmonauts (Fox, 2004).

Rhodiola Rosea - Medically Speaking

With over 200 species of Rhodiola itself, according to documented research and usage of the extracts of the root, R. rosea has proven to be the most clinically effective. In so far as clinical efficacy is concerned the reported use thereof within the treatment of a variety of conditions include the likes of Anxiety and Panic, Arrhythmia, Cancer, Chronic Fatigue Syndrome, Diabetes, Depression, Fatigue, Fibromyalgia, High Blood Pressure, and Stress. All tests conducted within animal studies suggest benefits were indicative and in some cases additional research was in fact required. (WholeHealthMD.com Supplements, 2009)

The effects of using the natural products derived from Rhodiola rosea are based upon the neurochemical mechanisms and processes associated with the inhibition of monoamine oxidize which in turn have a regulatory or changing effect on dopamine and serotonin levels. These neurotransmitters have been proven to contribute to feelings of well being, within the case of the latter, whilst the former has been linked to significant processes within the brain, including memory, cognitive processes, learning, motivation processes and a number of additional processes (Kelly, 2001), thereby providing a positive link within the reported benefits of using the Rhodiola rosea products.

Within the analysis of the components or structure of Rhodiola rosea, specifica investigative and analytical studies have shown that a number of compounds contained within the plant itself may well contribute to the efficacy of the use of this. The class of rosavins being rosarin, rosin and rosvin are contained within the Rhodiola rosea, together with the most active components of tyrosol and rhodioloside, which in turn during studies and trials have shown a synergistic effect together with the mentioned rosavins. (Kucinskaite A, 2004; Mao Y, 2007; Panossian A, 2008)

Rhodiola Rosea as a treatment for depression

Scientifically researched and proven as an effective treatment of depression, Rhodiola Rosea has been formulated and made available within a number of options, ranging from capsules, tablets and tinctures. Although specific dosage requirements have not been openly published, users thereof are recommended to adhere to producer recommendations and dosage instructions, although consensus seems to indicate that dosage within the region of 340mg per day is suggested for depression. Statistically speaking research has revealed that depression will occur, as a first episode between the ages of 25 and 44 years old – and losses incurred as a result of treatment, personnel replacement, medical care and the actual loss of life result in costs within the region of $35 billion or more.

Rhodiola Rosea as an “Adaptogen”

Alternatively referred to as an endurance enhancer, the qualities of Rhodiola have been documented as providing the body with health and performance attributes despite significantly exhaustive conditions and stresses upon the body itself – hence the aforementioned claim to fame within the use thereof from the perspective of Soviet athletic professionals and cosmonauts exposed to the environmental stresses of space travel and exploration.

Rhodiola Rosea as an effective treatment for Age-Associated Memory Impairment (AAMI)

Affecting 6% of the US population, and almost 1 in 5 of people over the age 50 years old, AAMI has not been associated with any specific disease or condition as such. One of the contributing factors to memory impairment regardless of age is that of stress and fatigue, which are often times brought about by physical exertion as well as exposure to environmental stresses and toxins. The two specific conditions have been effectively treated with Rhodiola, as provided above.

Rhodiola Rosea as a treatment for Hashimoto’s Disease

Hashimoto’s disease is classified as an autoimmune disease, within which the cells of the body work towards destroying the Thyroid gland. Although no scientific study has provided specific proof or analysis of the treatment of Hashimoto’s disease with Rhodiola, the use thereof is associated within the treatment of fatigue associated to thyroid related issues and diseases (Kharrazian, 2009).

Rhodiola Rosea as a treatment for Lyme’s Disease

Lyme’s disease is contracted when humans are bitten by ticks that have been infected with the Borrelia burgdorferi bacterium. This is often treated with antibiotics, and those affected can suffer from brain, heart and joint problems. There is no scientific proof to suggest that Rhodiola is effective within the treatment of Lyme’s, however there are published accounts of significant improvements in memory and mobility following a treatment with Rhodiola (Brown, Gerbarg, & Graham, 2004).

Rhodiola Rosea reported optimal dosage, and potential side effects

In so far as side effects are concerned, the use of Rhodiola Rosea has not revealed any specific or notable side effects per se, however it has been reported that the use thereof can impact upon sleep patterns, and within which instance the dosage thereof is recommended to be within the early to mid afternoon for individuals susceptible as such. Additionally already existing conditions, such as bi-polar disorder or people with known allergies should in fact consult a physician specialist prior to undertaking any course or single dose of Rhodiola Rosea to be on the safe side.

From a dosage perspective, a number of different dosages are recommended, and as previously mentioned the best route to follow is arguably that of the manufacturer or producer of the specific product in question. And in having mentioned that there has been no systematic testing of dosage amounts exceeding 400mg, and therefore there is no conclusive evidence that suggests any additional benefits of excessive dosage above the amount of 400mg, even though there are products supplying capsules within the 1,000mg range (Brown, Gerbarg, & Graham, 2004).

Ideally the time of dosage is prior to a mealtime, and preferably before breakfast and / or lunch. This allows for greater absorption of the compounds and active ingredients within Rhodiola Rosea and thereby allowing for quicker processing into the blood stream and respective cellular barriers. One can also take during mealtimes, although the optimal issue of absorption will be forsaken in this instance. As previously mentioned with report impact upon sleep, within the event of forgetting the dosage, one should not take the required dosage in the late afternoon or in the evening and the continued dosing should be taken the following day to avoid any such sleeplessness or related side effects.

References:

Brown, R. P., Gerbarg, P. L., & Graham, B. (2004). The rhodiola revolution : transform your health with the herbal breakthrough of the 21st century. Emmaus: St, Martin's Press.

Fox, W. S. (2004). 100 & healthy : living longer with phytomedicines from the Republic of Georgia. Orem, Utah: Woodland.

Kelly, G. S. (2001). Rhodiola rosea: a possible plant adaptogen. Alternative Medicine Review , 293–302.

Kharrazian, D. (2009). Why Do I Still Have Thyroid Symptoms? When My Lab Tests Are Normal: A Revolutionary Breakthrough In Understanding Hashimoto's Disease and Hypothyroidism. Garden City, NY: Morgan James Publishing.

Kucinskaite A, B. V. (2004). Experimental analysis of therapeutic properties of Rhodiola rosea L. and its possible application in medicine. Medicina (Kaunas) , 614–9.

Mao Y, L. Y. (2007). Simultaneous determination of salidroside and tyrosol in extracts of Rhodiola L. by microwave assisted extraction and high-performance liquid chromatography. J Pharm Biomed Anal , 510–5.

Panossian A, N. N. (2008). Comparative study of Rhodiola preparations on behavioral despair of rats. Phytomedicine , 84–91. WholeHealthMD.com Supplements. (2009, October 10). Retrieved 02 09, 2011, from Whole Health MD: http://www.wholehealthmd.com/ME2/dirmod.asp?sid=17E09E7CFFF640448FFB0B4FC1B7FEF0&nm=Reference+Library&type=AWHN_Supplements&mod=Supplements&mid=&id=BC6009ED692E4496AB9D44084CC3E746&tier=2


J Strength Cond Res. 2005 May;19(2):358-63.
Colson SN, Wyatt FB, Johnston DL, Autrey LD, Fitzgerald YL, Earnest CP.
Department of Health Sciences, McLennan Community College, Waco, Texas 76708, USA.

Cordyceps sinensis- and Rhodiola rosea-based supplementation in male cyclists and its effect on muscle tissue oxygen saturation.

Cordyceps sinensis (Cs) and Rhodiola rosea (Rr) are herbs used in traditional Chinese medicine to treat a multitude of ailments as well as to enhance performance. The purpose of this research was to examine the effects of a formula containing Cs and Rr (Cs-Rr) on circulatory dynamics, specifically muscle tissue oxygen saturation (Sto(2)), in male subjects during maximal exercise. This study followed a double blind, randomized, placebo-treatment, pre-post test design. Capsules were administered to 8 subjects who were randomly assigned to 1 of 2 groups. The treatment group received Cs-Rr, and the control group received a placebo. All subjects performed 2 exercise stress tests to volitional fatigue on a cycle load ergometer. There were no significant (p


Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005 May;25(5):445-8.
Li J, Fan WH, Ao H.
Department of Cardiac Diseases, Huashan Hospital, Fudan University, Shanghai.

Effect of rhodiola on expressions of Flt-1, KDR and Tie-2 in rats with ischemic myocardium.

OBJECTIVE: To investigate the effect of rhodiola on expression of vascular endothelial growth factors receptors (VEGFR) in myocardium of rats after myocardial infarction. METHODS: On the basis of successful establishment of myocardial infarction rat model, the experimental animals were divided into the model group, the rhodiola group, the positive control group and the sham-operated group, they were sacrificed after 6 weeks feeding. Their hearts were resected and embedded in paraffin to make sections with standard immunohistochemistry stain. Then the stained slices were analyzed in the IMS cell imagine analysis system using immunohistochemical quantitative analysis software. The field of vision of left ventricular myocardial tissue in three sites selected from the marginal area of infarction in each slice were determined, the mean value was then converted to positive area. Meanwhile, the mean optical density (OD) was calculated and the various expressions of VEGFR, i.e. Flt-1, KDR and angiopoietin receptor (Tie-2) were measured. RESULTS: The expressions of Flt-1 and Tie-2 in myocardial tissue were significantly increased in the rhodiola treated group after treatment, showing significant difference as compared with those in the positive control group and the model group (P < 0.05). The expression of KDR in myocardium after rhodiola intervention was higher than that in the sham-operated and nonintervened group (P < 0.05), but insignificantly different to that in the positive control group and model group. CONCLUSION: Rhodiola could improve angiogenesis to ameliorate myocardial ischemia by regulating the expression of Flt-1 and Tie-2 in ischemic myocardium.


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