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Rosuvastatin Review Article

 

Rosuvastatin is basically use for the treatment of high cholesterol and to prevent cardiovascular disease. It is a member of class statins. Rosuvastatin works by reducing levels of low density lipoprotein cholesterol and triglycerides in the blood while increasing levels of high density lipoprotein (HDL). Lowering cholesterol can help prevent heart disease and hardening of arteries that can lead to heart attack, stroke and vascular disease. Rosuvastatin calcium is a synthetic lipid lowering agent approved as a treatment for hypercholesterolemia. It is a part of complete program that also includes diet, exercise and weight control. It is recommended not to take this medication if allergic to rosuvastatin, have liver disease or if you are pregnant or breast feeding a baby.

Rosuvastatin generic (generic - what is it?)

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10 mg 90 tab ($0.71 per tab) USD 64.00 Add to Basket
20 mg 30 tab ($1.40 per tab) USD 42.00 Add to Basket
20 mg 90 tab ($0.99 per tab) USD 89.00 Add to Basket

Indications and regulation:
Rosuvastatin is approved for the treatment of high LDL cholesterol (dyslipidemia), total cholesterol (hypercholesterolemia) and/or triglycerides (hypertriglyceridemia).
As of 2004, rosuvastatin had been approved in 154 countries and launched in 56. Approval in the United States by the FDA came on August 12, 2003.
In 2008, research emerged that rosuvastatin could reduce the risk of heart attack, stroke, and other vascular complications in patients with elevated C-reactive protein but no other risk factors. This could strongly impact medical practice by placing many patients on statin prophylaxis that otherwise would have been untreated.
The results of the JUPITER trial suggested that rosuvastatin may decrease the relative risk of heart attack and stroke in patients without hyperlipidemia.
The AURORA trial randomized 2776 patients undergoing hemodialysis to receive either rosuvastatin or placebo. The randomized, double-blind study found no difference in the two groups in the primary end point, a combination of cardiovascular mortality, nonfatal myocardial infarction, or nonfatal stroke. The study found no difference in all-cause mortality among this population at a mean follow up of 3.8 years.

Effects on cholesterol levels
The effects of rosuvastatin on LDL cholesterol are dose-related. At the 10 mg dose, the average LDL cholesterol reduction was found to be 46% in one trial. Increasing the dose from 10 mg to 40 mg gave a modest increase of an additional 9% absolute reduction in LDL levels (55% below baseline levels).

Mechanism of action:
Rosuvastatin is a competitive inhibitor of the enzyme HMG-CoA reductase, having a mechanism of action similar to other statins. Its approximate elimination half life is 19 hours and its time to peak plasma concentration are reached in 35 hours following oral administration.

Rosuvastatin is available as Crestor in tablet form (5, 10, 20, or 40 mg) for oral administration. Tablets are pink, round or oval (40 mg), biconvex, film-coated, and imprinted with "ZD4522" and tablet strength. Japanese approval is in the dose range of 2.5 mg to 20 mg; therefore, smaller dose tablet forms might also be available outside the United States. Note that 97% of worldwide sales have been at or below the 20 mg dose.


Rosuvastatin notes:

Rosuvastatin from the class of drugs statins is is used to lower cholesterol and triglycerides in the blood. It helps in preventing problems like atherosclerosis (hardening of the arteries) which are caused by fats clogging the blood vessels.

Rosuvastatin side effects includes dark-colored urine, muscle cramps, skin rash, vomiting of blood, yellow eyes or skin, congestion, dry or sore throat, swollen glands in the neck, sour stomach, bladder pain, blurred vision, chest pain, depression, diarrhea, dry mouth, feeling of warmth or heat, increased urination, pain or swelling in the arms or legs without any injury.

The recommended dosage of Rosuvastatin is 5 to 40 milligrams once a day in adults for high cholesterol or as prescribed by doctor. If a dose is missed take it immediately as soon as remembered, if its the time for next dose skip the missed one and continue with the regular routine.

Seek emergency medical attention if an overdose of this medication is detected.

This medication is a competitive inhibitor of the enzyme HMG-CoA reductase, having a mechanism of action similar to other statins. Its approximate elimination half life is 19 hours and its time to peak plasma concentration are reached in 35 hours following oral administration.

Other drugs like Acenocoumarol, Amiodarone, Dicumarol, Eltrombopag, Ethynodiol, Fluconazole, Mestranol, Norethindrone may interact with Rosuvastatin. It is recommended not to take alcohol and grapefruit juice along with this medication as it can increase risk of certain side effects.

Consult doctor before taking Rosuvastatin if you are pregnant or planning to become pregnant during the treatment. No information is available whether this medication passes to infants through breast milk.

Store the medicine in a closed container at room temperature away from heat, moisture and direct light.


 

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